Global Burden of Colistin-Resistant Bacteria: Mobilized Colistin Resistance Genes Study (1980–2018)

Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of m...

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Published inMicroorganisms (Basel) Vol. 7; no. 10; p. 461
Main Authors Elbediwi, Mohammed, Li, Yan, Paudyal, Narayan, Pan, Hang, Li, Xiaoliang, Xie, Shaohua, Rajkovic, Andreja, Feng, Youjun, Fang, Weihuan, C. Rankin, Shelley, Yue, Min
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 16.10.2019
MDPI
Subjects
Animals
antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial diseases
bacterial infections
China
Colistin
Documents
Drug resistance
E coli
Escherichia coli
Food
food animals
Food products
food-chain
foods
Genes
genotype
Genotypes
Gram-negative bacteria
Health risks
humans
Meta-analysis
mobilized colistin resistance (mcr) genes
Multidrug resistance
multiple drug resistance
Observational studies
Plasmids
Poultry
Public health
reservoir
resistance genes
Reviews
Salmonella
Systematic review
China
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Abstract Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1–9.3%). China reported the highest number of mcr-positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid.
AbstractList Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance ( mcr ) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1–9.3%). China reported the highest number of mcr -positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid.
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1–9.3%). China reported the highest number of mcr-positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid.
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1−9.3%). China reported the highest number of mcr-positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid.
Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1-9.3%). China reported the highest number of mcr-positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid.Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global dissemination of mobilized colistin resistance (mcr) genes is an urgent public health threat. An accurate estimate of the global prevalence of mcr genes, their reservoirs and the potential pathways for human transmission are required to implement control and prevention strategies, yet such data are lacking. Publications from four English (PubMed, Scopus, the Cochrane Database of Systematic Reviews and Web of Science) and two Chinese (CNKI and WANFANG) databases published between 18 November 2015 and 30 December 2018 were identified. In this systematic review and meta-analysis, the prevalence of mcr genes in bacteria isolated from humans, animals, the environment and food products were investigated. A total of 974 publications were identified. 202 observational studies were included in the systematic review and 71 in the meta-analysis. mcr genes were reported from 47 countries across six continents and the overall average prevalence was 4.7% (0.1-9.3%). China reported the highest number of mcr-positive strains. Pathogenic Escherichia coli (54%), isolated from animals (52%) and harboring an IncI2 plasmid (34%) were the bacteria with highest prevalence of mcr genes. The estimated prevalence of mcr-1 pathogenic E. coli was higher in food-animals than in humans and food products, which suggests a role for foodborne transmission. This study provides a comprehensive assessment of prevalence of the mcr gene by source, organism, genotype and type of plasmid.
Author Fang, Weihuan
Xie, Shaohua
Feng, Youjun
Yue, Min
Paudyal, Narayan
Rajkovic, Andreja
Li, Yan
Li, Xiaoliang
C. Rankin, Shelley
Elbediwi, Mohammed
Pan, Hang
AuthorAffiliation 7 Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; srankin@vet.upenn.edu
1 Institute of Preventive Veterinary Sciences, Zhejiang University College of Animal Sciences, Hangzhou 310058, China; m.elbediwi@zju.edu.cn (M.E.); yanli3@zju.edu.cn (Y.L.); narayan.paudyal@outlook.com (N.P.); 11817015@zju.edu.cn (H.P.); xlli@zju.edu.cn (X.L.); whfang@zju.edu.cn (W.F.)
3 Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou 310058, China
4 Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, 17176 Stockholm, Sweden; shaohua.xie@ki.se
6 Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, Hangzhou 310058, China; fengyj@zju.edu.cn
2 Nepal Agricultural Research Council (NARC), Animal Health Research Division (AHRD), Kathmandu 5459, Nepal
5 Department of Food technology, Food safety and Health, Faculty
AuthorAffiliation_xml – name: 4 Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, 17176 Stockholm, Sweden; shaohua.xie@ki.se
– name: 7 Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; srankin@vet.upenn.edu
– name: 3 Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Hangzhou 310058, China
– name: 2 Nepal Agricultural Research Council (NARC), Animal Health Research Division (AHRD), Kathmandu 5459, Nepal
– name: 1 Institute of Preventive Veterinary Sciences, Zhejiang University College of Animal Sciences, Hangzhou 310058, China; m.elbediwi@zju.edu.cn (M.E.); yanli3@zju.edu.cn (Y.L.); narayan.paudyal@outlook.com (N.P.); 11817015@zju.edu.cn (H.P.); xlli@zju.edu.cn (X.L.); whfang@zju.edu.cn (W.F.)
– name: 5 Department of Food technology, Food safety and Health, Faculty of Bioscience Engineering, Ghent University, 9000 Ghent, Belgium; andreja.rajkovic@ugent.be
– name: 6 Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, Hangzhou 310058, China; fengyj@zju.edu.cn
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  givenname: Mohammed
  orcidid: 0000-0003-3834-8523
  surname: Elbediwi
  fullname: Elbediwi, Mohammed
– sequence: 2
  givenname: Yan
  surname: Li
  fullname: Li, Yan
– sequence: 3
  givenname: Narayan
  orcidid: 0000-0001-8204-2674
  surname: Paudyal
  fullname: Paudyal, Narayan
– sequence: 4
  givenname: Hang
  surname: Pan
  fullname: Pan, Hang
– sequence: 5
  givenname: Xiaoliang
  surname: Li
  fullname: Li, Xiaoliang
– sequence: 6
  givenname: Shaohua
  orcidid: 0000-0002-4270-1281
  surname: Xie
  fullname: Xie, Shaohua
– sequence: 7
  givenname: Andreja
  surname: Rajkovic
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  orcidid: 0000-0002-7578-540X
  surname: C. Rankin
  fullname: C. Rankin, Shelley
– sequence: 11
  givenname: Min
  orcidid: 0000-0002-6787-0794
  surname: Yue
  fullname: Yue, Min
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Snippet Colistin is considered to be an antimicrobial of last-resort for the treatment of multidrug-resistant Gram-negative bacterial infections. The recent global...
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SubjectTerms Animals
antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial diseases
bacterial infections
China
Colistin
Documents
Drug resistance
E coli
Escherichia coli
Food
food animals
Food products
food-chain
foods
Genes
genotype
Genotypes
Gram-negative bacteria
Health risks
humans
Meta-analysis
mobilized colistin resistance (mcr) genes
Multidrug resistance
multiple drug resistance
Observational studies
Plasmids
Poultry
Public health
reservoir
resistance genes
Reviews
Salmonella
Systematic review
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Title Global Burden of Colistin-Resistant Bacteria: Mobilized Colistin Resistance Genes Study (1980–2018)
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https://www.proquest.com/docview/2307132777
https://www.proquest.com/docview/2400501430
https://pubmed.ncbi.nlm.nih.gov/PMC6843232
https://doaj.org/article/d021be6fe4c149f8867156dd1deb6784
Volume 7
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