Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study

• Published in: Thrombosis and haemostasis Vol. 109; no. 2; p. 347
• Main Authors: Saucedo, Jorge F, Angiolillo, Dominick J, DeRaad, Roger, Frelinger, 3rd, Andrew L, Gurbel, Paul A, Costigan, Timothy M, Jakubowski, Joseph A, Ojeh, Clement K, Duvvuru, Suman, Effron, Mark B
• Format: Journal Article
• Language: English
• Published: Germany 01.02.2013
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - drug therapy; Aged; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Blood Platelets - drug effects; Blood Platelets - metabolism; Cell Adhesion Molecules - blood; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Substitution; Female; Genotype; Humans; Male; Microfilament Proteins - blood; Middle Aged; Pharmacogenetics; Phenotype; Phosphoproteins - blood; Piperazines - administration & dosage; Piperazines - adverse effects; Piperazines - metabolism; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - metabolism; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists - administration & dosage; Purinergic P2Y Receptor Antagonists - adverse effects; Purinergic P2Y Receptor Antagonists - metabolism; Receptors, Purinergic P2Y12 - blood; Receptors, Purinergic P2Y12 - drug effects; Thiophenes - administration & dosage; Thiophenes - adverse effects; Thiophenes - metabolism; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Ticlopidine - metabolism; Treatment Outcome

The prevalence of high platelet reactivity (HPR) in patients who have switched from clopidogrel to prasugrel during maintenance phase after an acute coronary syndrome (ACS) event is unknown. Therefore, the effect of switching from clopidogrel to prasugrel on the prevalence of HPR was evaluated. This...