Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

• Published in: Cell death and differentiation Vol. 22; no. 3; pp. 433 - 444
• Main Authors: Menzies, F M, Garcia-Arencibia, M, Imarisio, S, O'Sullivan, N C, Ricketts, T, Kent, B A, Rao, M V, Lam, W, Green-Thompson, Z W, Nixon, R A, Saksida, L M, Bussey, T J, O'Kane, C J, Rubinsztein, D C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2015; Nature Publishing Group
• Subjects: 631/378/1689/1558; 631/80/82/39; 692/700/565/1436/2185; Animals; Apoptosis; Autophagy - drug effects; Biochemistry; Biomedical and Life Sciences; Calcium-Binding Proteins - biosynthesis; Calpain - antagonists & inhibitors; Calpain - genetics; Calpain - metabolism; Cell Biology; Cell Cycle Analysis; Disease Models, Animal; Drosophila; Drosophila Proteins - antagonists & inhibitors; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Female; Gene Knockdown Techniques; Huntington Disease - enzymology; Huntington Disease - metabolism; Huntington Disease - pathology; Huntington Disease - therapy; Inbreeding; Life Sciences; Male; Mice; Mice, Inbred C57BL; Original Paper; Peptides - metabolism; Signal Transduction; Stem Cells

Over recent years, accumulated evidence suggests that autophagy induction is protective in animal models of a number of neurodegenerative diseases. Intense research in the field has elucidated different pathways through which autophagy can be upregulated and it is important to establish how modulati...