Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease

• Published in: Chinese medical journal Vol. 130; no. 24; pp. 2978 - 2990
• Main Authors: Wu, Xi-Lin, Piña-Crespo, Juan, Zhang, Yun-Wu, Chen, Xiao-Chun, Xu, Hua-Xi
• Format: Journal Article
• Language: English
• Published: China Medknow Publications and Media Pvt. Ltd 20.12.2017; Lippincott Williams & Wilkins Ovid Technologies; Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian 350001, China%Neuroscience Initiative, Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA%Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen,Fujian 361102, China%Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, Fujian 350001, China%Neuroscience Initiative, Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Neuroscience Initiative, Neuroscience and Aging Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen,Fujian 361102, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Aging; Alzheimer Disease - diagnosis; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer's disease; Alzheimer's Disease; Biomarker; Immunotherapy; Tau Imaging; Tau Protein; Transcellular Propagation; Amyloid beta-protein; Animals; Autophagy; Biological markers; Brain research; Care and treatment; Dementia; Diagnosis; Geriatrics; Humans; Immunotherapy; Kinases; Laboratories; Neurodegeneration; Neurodegenerative Diseases - metabolism; Neurology; Neurosciences; Pathogenesis; Pathology; Phosphorylation; Physiology; Prevention; Proteins; Research centers; Review; tau Proteins - metabolism; Tau Imaging; Biomarker; Tau Protein; Alzheimer's Disease; Immunotherapy; Transcellular Propagation

To review recent research advances on tau, a major player in Alzheimer's disease (AD) pathogenesis, a biomarker for AD onset, and potential target for AD therapy. This review was based on a comprehensive search using online literature databases, including PubMed, Web of Science, and Google Scho...