Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice

• Published in: American journal of human genetics Vol. 98; no. 1; pp. 102 - 115
• Main Authors: Gruhn, Jennifer R., Al-Asmar, Nasser, Fasnacht, Rachael, Maylor-Hagen, Heather, Peinado, Vanessa, Rubio, Carmen, Broman, Karl W., Hunt, Patricia A., Hassold, Terry
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.01.2016; Cell Press; Elsevier
• Subjects: Animals; Cell division; Correlation analysis; Female; Genomics; Human subjects; Humans; Male; Meiosis - genetics; Mice; Recombination, Genetic; Rodents; Synapses - physiology

Meiotic recombination is initiated by programmed double strand breaks (DSBs), only a small subset of which are resolved into crossovers (COs). The mechanism determining the location of these COs is not well understood. Studies in plants, fungi, and insects indicate that the same genomic regions are...