Transcription alterations of members of the ubiquitin–proteasome network in prostate carcinoma

• Published in: Prostate cancer and prostatic diseases Vol. 14; no. 1; pp. 38 - 45
• Main Authors: Hellwinkel, O J C, Asong, L E, Rogmann, J-P, Sültmann, H, Wagner, C, Schlomm, T, Eichelberg, C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2011; Nature Publishing Group
• Subjects: 631/208/200; 692/699/67/589/466; Adult; Aged; ATPases Associated with Diverse Cellular Activities; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer Research; Carcinoma - metabolism; Carcinoma - pathology; Care and treatment; Degradation; Diagnosis; Endosomal Sorting Complexes Required for Transport - genetics; Endosomal Sorting Complexes Required for Transport - metabolism; Epithelial cells; Epithelium; Genes; Genetic aspects; Genetic transcription; Growth factors; Humans; Labeling; Male; Markers; Middle Aged; Nedd4 Ubiquitin Protein Ligases; original-article; Physiological aspects; Pilot Projects; Polymerase chain reaction; Prostate; Prostate cancer; Prostate carcinoma; Prostatectomy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Proteasomes; Proteins; Signal Transduction; Solid tumors; Transcription; Transcription, Genetic; Transforming Growth Factor beta - metabolism; Tumor suppressor genes; Tumorigenesis; Tumors; Ubiquitin; Ubiquitin-proteasome system; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Germany; proteasome; tumour marker; E3 ubiquitin ligase; transcription; prostate carcinoma

The purpose of this work was to investigate the role of the ubiquitin–proteasome network (UPN) in prostate cancer (PCA) and to elicit potential markers for this disease. The UPN represents a key factor in the maintenance of cellular homoeostasis as a result of its fundamental function in the regulat...