HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 7; pp. 2647 - 2652
• Main Authors: Malvaez, Melissa, McQuown, Susan C., Rogge, George A., Astarabadi, Mariam, Jacques, Vincent, Carreiro, Samantha, Rusche, James R., Wood, Marcelo A.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences 12.02.2013; National Acad Sciences
• Series: From the Cover
• Subjects: Acetylation; Acetylation - drug effects; Acrylamides - blood; Acrylamides - pharmacokinetics; Acrylamides - pharmacology; adverse effects; Analysis of Variance; Animal behavior; Animal memory; Animals; Behavioral neuroscience; Biological and medical sciences; Biological Sciences; Chromatin Immunoprecipitation; Cocaine; cortex; Drug seeking behavior; Drug-Seeking Behavior - drug effects; Extinction; Extinction, Psychological - drug effects; Fluorescent Antibody Technique; Fundamental and applied biological sciences. Psychology; Gene expression; hippocampus; histone deacetylase; Histone Deacetylase Inhibitors - blood; Histone Deacetylase Inhibitors - pharmacokinetics; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylases - metabolism; Histones; Histones - metabolism; Learning; Male; Medical sciences; Memory; Memory interference; Mice; Mice, Inbred C57BL; Neuropharmacology; Pharmacology. Drug treatments; Phenylenediamines - blood; Phenylenediamines - pharmacokinetics; Phenylenediamines - pharmacology; Protease inhibitors; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Real-Time Polymerase Chain Reaction; Rodents; T tests; Time Factors; Vehicles; Vertebrates: nervous system and sense organs; Chromatin; CNS stimulant; Psychotropic; Memory; Drug of abuse; Cocaine; Behavior; Long term; long-term memory; epigenetics
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.1213364110

Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP96...