Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

• Published in: Nature genetics Vol. 38; no. 2; pp. 240 - 244
• Main Authors: Dietrich, William F, Boyden, Eric D
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2006; Nature Publishing Group
• Subjects: Agriculture; Alleles; Animal Genetics and Genomics; Animals; Anthrax; Antigens, Bacterial - toxicity; Apoptosis Regulatory Proteins - antagonists & inhibitors; Apoptosis Regulatory Proteins - metabolism; Bacillus anthracis; Bacterial toxins; Bacterial Toxins - toxicity; Base Sequence; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Caspase 1 - metabolism; Cell Survival; Cellular biology; Complications and side effects; Diagnosis; Disease Susceptibility; Edema; Enzymes; Exons - genetics; Fundamental and applied biological sciences. Psychology; Gene Function; Gene loci; Genetic aspects; Genetics of eukaryotes. Biological and molecular evolution; Genomics; Human Genetics; letter; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Macrophages - pathology; Mice; Mice, Transgenic; Molecular Sequence Data; Mortality; Pathology; Physiological aspects; Polymorphism, Genetic; Risk factors; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Toxins; United States; Infection; Toxin; Vertebrata; Regulation(control); Mammalia; Mouse; Anthrax; Rodentia; Bacteriosis; Macrophage

The pathogenesis of Bacillus anthracis, the bacterium that causes anthrax, depends on secretion of three factors that combine to form two bipartite toxins. Edema toxin, consisting of protective antigen (PA) and edema factor (EF), causes the edema associated with cutaneous anthrax infections, whereas...