Ssu72 phosphatase is a conserved telomere replication terminator

• Published in: The EMBO journal Vol. 38; no. 7
• Main Authors: Escandell, Jose Miguel, Carvalho, Edison SM, Gallo‐Fernandez, Maria, Reis, Clara C, Matmati, Samah, Luís, Inês Matias, Abreu, Isabel A, Coulon, Stéphane, Ferreira, Miguel Godinho
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2019; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Amino Acid Sequence; Biochemistry, Molecular Biology; Carrier Proteins - genetics; Cellular Biology; Chromosomes; Conserved Sequence; CST; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA Replication; DNA-directed DNA polymerase; Elongation; EMBO13; EMBO31; Evolution, Molecular; Fission; fission yeast; Genomes; Homeostasis; Homology; Humans; lagging‐strand synthesis; Life Sciences; Molecular biology; Phosphatase; Phosphoprotein Phosphatases - genetics; Phosphoric Monoester Hydrolases - genetics; Phosphorylation; Recruitment; Replication; Schizosaccharomyces - enzymology; Schizosaccharomyces - genetics; Schizosaccharomyces pombe Proteins - genetics; Sequence Homology; SSU72; Subcellular Processes; Synthesis; Telomerase; telomere; Telomere - genetics; Telomere Homeostasis; Telomeres; Yeast; lagging‐strand synthesis; SSU72; fission yeast; CST; telomere; lagging-strand synthesis; Post-translational Modifications; Repair & Recombination; telomere Subject Categories DNA Replication; Proteolysis & Proteomics

Telomeres, the protective ends of eukaryotic chromosomes, are replicated through concerted actions of conventional DNA polymerases and elongated by telomerase, but the regulation of this process is not fully understood. Telomere replication requires (Ctc1/Cdc13)‐Stn1‐Ten1, a telomeric ssDNA‐binding...