Expression of Epstein–Barr virus‐induced gene 3 and other interleukin‐12‐related molecules by human intestinal epithelium

• Published in: Immunology Vol. 112; no. 3; pp. 437 - 445
• Main Authors: Maaser, Christian, Egan, Laurence J., Birkenbach, Mark P., Eckmann, Lars, Kagnoff, Martin F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.2004; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Animals; Cell Line; Epithelial Cells - immunology; Epstein-Barr virus; Epstein–Barr virus‐induced gene‐3; Glycoproteins - analysis; Glycoproteins - immunology; Humans; IL‐12p35; IL‐12‐related molecules; Immunity, Mucosal; Immunoblotting - methods; Immunohistochemistry - methods; Interleukin-12 - analysis; Interleukin-12 - immunology; Interleukins; intestinal epithelial cells; intestinal xenograft; Intestines - immunology; Mice; Mice, Inbred C57BL; Mice, SCID; Minor Histocompatibility Antigens; Original; p19; p28; Receptors, Cytokine - analysis; Receptors, Cytokine - immunology; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous

Summary Antigen‐presenting cells, including dendritic cells, monocytes and macrophages, produce members of the interleukin‐12 (IL‐12) family that are important in initiating and maintaining cell‐mediated immune responses. These include IL‐12p35 and p19 that dimerize with IL‐12p40 to form IL‐12 (also...