Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction - Wang, Xinglong; Petrie, Timothy G.; Liu, Yingchao; Liu, Jun; Fujioka, Hisashi; Zhu, Xiongwei (Journal of neurochemistry, 2012)
Keywords: Biological and medical sciences; Blotting, Western; Brain; Cell Line; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DJ-1; Drp1; Elongation; Fluorescent Antibody Technique; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Hippocampus; Humans; Hydrogen peroxide; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Medical sciences; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - ultrastructure; mitochondrial elongation; mitochondrial fragmentation; mitochondrial fusion; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Movement disorders; MPP super(+); Mutation; Neuroblastoma cells; Neurochemistry; Neurodegeneration; Neurodegenerative diseases; Neurology; Neurons; Neurotoxins; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Overexpression; Oxidative stress; PARK7 protein; Parkinson disease; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Protein Deglycase DJ-1; Transfection; Tumors of the nervous system. Phacomatoses; Cell function; Pathogenesis; Central nervous system; Parkinson disease; DJ-1; Neuroblastoma; Encephalon; Drp1; mitochondrial fragmentation; Mitochondria; Dynamics; Degenerative disease; Degeneration; Human; Nervous system diseases; Functional analysis; Vulnerability; Malignant tumor; mitochondrial fusion; Cerebral disorder; mitochondrial elongation; Neuron; Dysfunction; Central nervous system disease; Mutation; Autonomic neuropathy; Hippocampus; Cancer; Extrapyramidal syndrome