Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease - Docena, G; Rovedatti, L; Kruidenier, L; Fanning, Á; Leakey, N.A.B; Knowles, C.H; Lee, K; Shanahan, F; Nally, K; McLean, P.G; Di Sabatino, A; MacDonald, T.T (Clinical and experimental immunology, 2010)
Keywords: Adolescent; Adult; Analytical, structural and metabolic biochemistry; antagonists & inhibitors; Biological and medical sciences; Biopsy; Blotting, Western; Cell culture; Cells, Cultured; Crohn disease; Crohn's disease; Cytokines; Cytokines - metabolism; Down-Regulation; Down-Regulation - drug effects; drug effects; Drugs; Enzyme Activation; Enzyme Activation - drug effects; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; Enzyme-linked immunosorbent assay; enzymology; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Imidazoles; Imidazoles - pharmacology; Immune system; Immunoblotting; Inflammation; Inflammation Mediators; Inflammation Mediators - metabolism; Inflammatory bowel disease; Inflammatory Bowel Diseases; Inflammatory Bowel Diseases - enzymology; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - pathology; Interleukin 1; Interleukin 6; Interleukin-1beta; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Intestinal Mucosa; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Kinases; lamina propria; lamina propria mononuclear cell; Leukocytes (mononuclear); Male; MAP kinase; Medical sciences; metabolism; Middle Aged; Mucosa; Niacinamide; Niacinamide - pharmacology; Organ culture; Organ Culture Techniques; Other diseases. Semiology; p38 inhibitor; p38 Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases - metabolism; pathology; pharmacology; Phosphorylation; Phosphorylation - drug effects; Proteins; Pyridines; Pyridines - pharmacology; Pyrimidines; Pyrimidines - pharmacology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; TNF-α; Translational Studies; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Ulcerative colitis; Young Adult; Enzyme; Transferases; Cytokine; Lamina propria; Mitogen-activated protein kinase; Activation; Biochemistry; Biosynthesis; Inflammation; Crohn's disease; Inflammatory disease; Inflammatory bowel disease; Crohn disease; Regulation(control); Mononuclear cell; TNF-α