Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons

• Published in: Molecular psychiatry Vol. 12; no. 5; pp. 491 - 501
• Main Authors: Lim, J-E, Pinsonneault, J, Sadee, W, Saffen, D
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2007; Nature Publishing Group
• Subjects: Alleles; Allelic Imbalance - genetics; Anxiety disorders; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Exons; Gene expression; Gene Expression Regulation - genetics; Gene Expression Regulation - physiology; Genetic aspects; Genotyping; Haplotypes; Haplotypes - physiology; Health aspects; Heterozygosity; Humans; Hydroxylases; Isoenzymes - genetics; Isoenzymes - metabolism; Medical sciences; Medicine; Medicine & Public Health; Methods; mRNA processing; Neurosciences; original-article; Pharmacotherapy; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Pons; Pons - metabolism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Raphe nuclei; RNA, Messenger - metabolism; Serotonin; Serotonin metabolism; Single-nucleotide polymorphism; Suicide; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Tryptophan Hydroxylase - metabolism; United States; England; Ohio; United Kingdom > UK; United States > US; serotonin; haplotype; tryptophan hydroxylase 2; single nucleotide polymorphism (SNP); linkage disequilibrium (LD); ); allelic expression imbalance (AEI); Human; Serotonin; Enzyme; Gene expression; Genetic determinism; Tryptophan 5-monooxygenase; tryptophan hydroxylase 2 (TPH2); Neurotransmitter; Genetics; Oxidoreductases; Predictive factor; Haplotype; Polymorphism

Tryptophan hydroxylase isoform 2 (TPH2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. In search for functional polymorphisms within the TPH2 gene locus, we measured allele-specific expression of...