Cellular changes in the postmortem hippocampus in major depression

• Published in: Biological psychiatry (1969) Vol. 56; no. 9; pp. 640 - 650
• Main Authors: Stockmeier, Craig A., Mahajan, Gouri J., Konick, Lisa C., Overholser, James C., Jurjus, George J., Meltzer, Herbert Y., Uylings, Harry B.M., Friedman, Lee, Rajkowska, Grazyna
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2004; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Anatomy; Biological and medical sciences; Case-Control Studies; Cell Count - methods; Cell Size; Central nervous system; Depression; Depressive Disorder, Major - pathology; Female; Fundamental and applied biological sciences. Psychology; glia; hippocampus; Hippocampus - pathology; Humans; Imaging, Three-Dimensional - methods; Male; Medical sciences; Middle Aged; Mood disorders; Neuroglia - pathology; Neurons - pathology; Postmortem Changes; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; pyramidal neurons; Staining and Labeling - methods; Time Factors; Vertebrates: nervous system and sense organs; pyramidal neurons; Depression; hippocampus; glia; Mood disorder; Human; Healthy subject; Granule neuron; Central nervous system; Postmortem; Pyramidal neuron; Comparative study; Hippocampus; Encephalon; Cell density

Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not been identified. Sections of right hippocampus were collected in 19 subjects with MDD and 21 normal control subjects. The density of pyramida...