Establishment of serological neutralizing tests using pseudotyped viruses for comprehensive detection of antibodies against all 18 lyssaviruses

• Published in: Journal of Veterinary Medical Science Vol. 86; no. 1; pp. 128 - 134
• Main Authors: INOUE, Yusuke, KAKU, Yoshihiro, HARADA, Michiko, ISHIJIMA, Keita, KURODA, Yudai, TATEMOTO, Kango, VIRHUEZ-MENDOZA, Milagros, NISHINO, Ayano, YAMAMOTO, Tsukasa, PARK, Eun-sil, INOUE, Satoshi, MATSUU, Aya, MAEDA, Ken
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.01.2024; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Animals; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; Antisera; cross-reactivity; Glycoproteins; Lyssavirus; Neurological diseases; pseudotype; Rabbits; Rabies; Rabies - veterinary; Rabies Vaccines; Rabies virus; Stomatitis; vaccine; Vaccines; Viral Pseudotyping - veterinary; Virology; Zoonoses; rabies; vaccine; cross-reactivity; pseudotype; lyssavirus

Rabies is a fatal zoonotic, neurological disease caused by rabies lyssavirus (RABV) and other lyssaviruses. In this study, we established novel serological neutralizing tests (NT) based on vesicular stomatitis virus pseudotypes possessing all 18 known lyssavirus glycoproteins. Applying this system t...