A tension-induced mechanotransduction pathway promotes epithelial morphogenesis

• Published in: Nature (London) Vol. 471; no. 7336; pp. 99 - 103
• Main Authors: Zhang, Huimin, Landmann, Frédéric, Zahreddine, Hala, Rodriguez, David, Koch, Marc, Labouesse, Michel
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.03.2011; Nature Publishing Group
• Subjects: 631/136/1660; 631/80/79/2066; 692/698/1671/1668; Animals; Biological and medical sciences; Caenorhabditis elegans - cytology; Caenorhabditis elegans - embryology; Caenorhabditis elegans - enzymology; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - metabolism; Carrier Proteins - metabolism; Development Biology; Embryology: invertebrates and vertebrates. Teratology; Epidermis; Epidermis - cytology; Epidermis - embryology; Fundamental and applied biological sciences. Psychology; Genetic aspects; Hemidesmosomes - metabolism; Humanities and Social Sciences; Intermediate Filaments - metabolism; Kinases; letter; Life Sciences; Mechanotransduction, Cellular - physiology; Morphogenesis; multidisciplinary; Muscle Contraction - physiology; Muscles; Muscles - embryology; Muscles - physiology; Mutation; Organogenesis. Fetal development; Organogenesis. Physiological fonctions; p21-Activated Kinases - metabolism; Phenotype; Phosphorylation; Proteins; Science; Science (multidisciplinary); Signal Transduction; Tension; Wound healing; United States; Morphogenesis; Caenorhabditis elegans; Embryonic development; Helmintha; Epidermis; Nemathelminthia; Muscle; Mechanotransduction; Invertebrata; Epithelium; Nematoda

Pulled into shape The development and function of many organs depend not only on biochemical signals, but also on the ability of cells and tissues to respond biochemically to mechanical forces — mechanotransduction. Here, Michel Labouesse and colleagues describe a mechanotransduction pathway that li...