Arsenic-Induced Enhancement of Ultraviolet Radiation Carcinogenesis in Mouse Skin: A Dose-Response Study

• Published in: Environmental health perspectives Vol. 112; no. 5; pp. 599 - 603
• Main Authors: Burns, Fredric J., Uddin, Ahmed N., Wu, Feng, Nádas, Arthur, Rossman, Toby G.
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01.04.2004; National Institute of Environmental Health Sciences
• Subjects: Animals; Arsenic; Arsenites; Arsenites - toxicity; Cancer; Carcinogens, Environmental - toxicity; Carcinoma, Squamous Cell - chemically induced; Carcinoma, Squamous Cell - etiology; Cell cycle; Cocarcinogenesis; Disease Models, Animal; Dose response relationship; Dose-Response Relationship, Drug; Epidermis - pathology; Hyperplasia - chemically induced; Mice; Mice, Hairless; Neoplasms, Radiation-Induced - etiology; Neoplasms, Radiation-Induced - pathology; Potable water; Skin; Skin Neoplasms - chemically induced; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Sodium; Tumors; Ultraviolet Rays; Water Pollutants, Chemical - toxicity

The present study was designed to establish the form of the dose-response relationship for dietary sodium arsenite as a co-carcinogen with ultraviolet radiation (UVR) in a mouse skin model. Hairless mice (strain Skh1) were fed sodium arsenite continuously in drinking water starting at 21 days of age...