Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1

• Published in: Genes and immunity Vol. 4; no. 1; pp. 46 - 53
• Main Authors: JOHANSSON, S, LIE, B. A, TODD, J. A, POCIOT, F, NERUP, J, CAMBON-THOMSEN, A, KOCKUM, I, AKSELSEN, H. E, THORSBY, E, UNDLIEN, D. E
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.01.2003
• Subjects: Alleles; Analysis; Biological and medical sciences; Chi-Square Distribution; Confidence Intervals; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; DQA1 protein; Drb1 protein; Environmental impact analysis; Fundamental and applied biological sciences. Psychology; Gene expression; Genetic aspects; Genetic markers; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes; Haplotypes - genetics; Health aspects; Histocompatibility antigen HLA; Histocompatibility antigens; HLA histocompatibility antigens; HLA-DQ alpha-Chains; HLA-DQ Antigens - genetics; HLA-DQ beta-Chains; HLA-DR Antigens - genetics; HLA-DRB1 Chains; Humans; Linkage disequilibrium; Medicin och hälsovetenskap; Microbiology; Microsatellite Repeats - genetics; Microsatellites; Odds Ratio; Type 1 diabetes; Norway; Microbiology

Susceptibility to, and protection against development of type 1 diabetes (T1D) are primarily associated with the highly polymorphic exon 2 sequences of the HLA class II genes: DQB1, DQA1 and DRB1. However, several studies have also suggested that additional genes in the HLA complex influence T1D ris...