Type IV collagens regulate BMP signalling in Drosophila

• Published in: Nature Vol. 455; no. 7209; pp. 72 - 77
• Main Authors: Wang, Xiaomeng, Harris, Robin E., Bayston, Laura J., Ashe, Hilary L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.09.2008; Nature Publishing; Nature Publishing Group
• Subjects: Amino acids; Animals; Biological and medical sciences; Body Patterning; Bone morphogenetic proteins; Bone Morphogenetic Proteins - genetics; Bone Morphogenetic Proteins - metabolism; Cell Count; Cells; Collagen; Collagen Type IV - genetics; Collagen Type IV - metabolism; Drosophila; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; E coli; Embryology: invertebrates and vertebrates. Teratology; Embryos; Female; Fundamental and applied biological sciences. Psychology; Humanities and Social Sciences; Insects; Male; Methods; Molecular embryology; multidisciplinary; Ovary - cytology; Ovary - metabolism; Physiological aspects; Protein Binding; Proteins; Science; Science (multidisciplinary); Signal Transduction; Signals and signaling; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; Vertebrates; Embryonic development; Insecta; Drosophila; Dorsoventral axis; Protein; Drosophilidae; Morphogenesis; Molecular signal; Arthropoda; Collagen; Extracellular matrix; Invertebrata; Diptera

Dorsal–ventral patterning in vertebrate and invertebrate embryos is mediated by a conserved system of secreted proteins that establishes a bone morphogenetic protein (BMP) gradient. Although the Drosophila embryonic Decapentaplegic (Dpp) gradient has served as a model to understand how morphogen gra...