MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation
Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOX...
Saved in:
| Published in | The Journal of biological chemistry Vol. 284; no. 21; pp. 13987 - 14000 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
22.05.2009
American Society for Biochemistry and Molecular Biology |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase activity of MDM2. Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its cellular trafficking and the forkhead box of FOXO1. MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA causes accumulation of endogenous FOXO3A protein in cells and enhances the expression of FOXO target genes. In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of endogenous FOXO3A. These data suggest that MDM2 acts as an ubiquitin E3 ligase, downstream of p53, to regulate the degradation of mammalian FOXO factors. |
|---|---|
| AbstractList | Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase activity of MDM2. Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its cellular trafficking and the forkhead box of FOXO1. MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA causes accumulation of endogenous FOXO3A protein in cells and enhances the expression of FOXO target genes. In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of endogenous FOXO3A. These data suggest that MDM2 acts as an ubiquitin E3 ligase, downstream of p53, to regulate the degradation of mammalian FOXO factors. Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase activity of MDM2. Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its cellular trafficking and the forkhead box of FOXO1. MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA causes accumulation of endogenous FOXO3A protein in cells and enhances the expression of FOXO target genes. In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of endogenous FOXO3A. These data suggest that MDM2 acts as an ubiquitin E3 ligase, downstream of p53, to regulate the degradation of mammalian FOXO factors. Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase activity of MDM2. Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its cellular trafficking and the forkhead box of FOXO1. MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA causes accumulation of endogenous FOXO3A protein in cells and enhances the expression of FOXO target genes. In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of endogenous FOXO3A. These data suggest that MDM2 acts as an ubiquitin E3 ligase, downstream of p53, to regulate the degradation of mammalian FOXO factors.Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase activity of MDM2. Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its cellular trafficking and the forkhead box of FOXO1. MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA causes accumulation of endogenous FOXO3A protein in cells and enhances the expression of FOXO target genes. In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of endogenous FOXO3A. These data suggest that MDM2 acts as an ubiquitin E3 ligase, downstream of p53, to regulate the degradation of mammalian FOXO factors. Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO degradation is proteasome-mediated, although the ubiquitin E3 ligase for FOXO factors remains to be defined. We show that MDM2 binds to FOXO1 and FOXO3A and promotes their ubiquitination and degradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase activity of MDM2. Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its cellular trafficking and the forkhead box of FOXO1. MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA causes accumulation of endogenous FOXO3A protein in cells and enhances the expression of FOXO target genes. In cells stably expressing a temperature-sensitive p53 mutant, activation of p53 by shifting to permissive temperatures leads to MDM2 induction and degradation of endogenous FOXO3A. These data suggest that MDM2 acts as an ubiquitin E3 ligase, downstream of p53, to regulate the degradation of mammalian FOXO factors. |
| Author | Shimojima, Tsukasa Ramamoorthy, Sivapriya Nicosia, Santo V. Chen, Jiandong Chen, Lei Nawaz, Zafar Zhang, Yanping Zhang, Yingtao Bai, Wenlong Zhang, Xiaohong Fu, Wei Shen, Zheng Zhang, Mu Wang, Hengbin Ma, Qiuping Pledger, Jack W. Yang, Yonghua Li, Pengfei |
| AuthorAffiliation | Departments of ‡ Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, the Programs of ∥ Molecular Oncology and Experimental Therapeutics, H. Lee Moffitt Cancer Center, Tampa, Florida 33612, the § Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, the ¶ Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35233, and the ‡‡ Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27514 |
| AuthorAffiliation_xml | – name: Departments of ‡ Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612, the Programs of ∥ Molecular Oncology and Experimental Therapeutics, H. Lee Moffitt Cancer Center, Tampa, Florida 33612, the § Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, the ¶ Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35233, and the ‡‡ Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27514 |
| Author_xml | – sequence: 1 givenname: Wei surname: Fu fullname: Fu, Wei organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 2 givenname: Qiuping surname: Ma fullname: Ma, Qiuping organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 3 givenname: Lei surname: Chen fullname: Chen, Lei organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 4 givenname: Pengfei surname: Li fullname: Li, Pengfei organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 5 givenname: Mu surname: Zhang fullname: Zhang, Mu organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 6 givenname: Sivapriya surname: Ramamoorthy fullname: Ramamoorthy, Sivapriya organization: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136 – sequence: 7 givenname: Zafar surname: Nawaz fullname: Nawaz, Zafar organization: Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136 – sequence: 8 givenname: Tsukasa surname: Shimojima fullname: Shimojima, Tsukasa organization: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35233 – sequence: 9 givenname: Hengbin surname: Wang fullname: Wang, Hengbin organization: Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35233 – sequence: 10 givenname: Yonghua surname: Yang fullname: Yang, Yonghua organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 11 givenname: Zheng surname: Shen fullname: Shen, Zheng organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 12 givenname: Yingtao surname: Zhang fullname: Zhang, Yingtao organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 13 givenname: Xiaohong surname: Zhang fullname: Zhang, Xiaohong organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 14 givenname: Santo V. surname: Nicosia fullname: Nicosia, Santo V. organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 – sequence: 15 givenname: Yanping surname: Zhang fullname: Zhang, Yanping organization: Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27514 – sequence: 16 givenname: Jack W. surname: Pledger fullname: Pledger, Jack W. organization: Experimental Therapeutics, H. Lee Moffitt Cancer Center, Tampa, Florida 33612 – sequence: 17 givenname: Jiandong surname: Chen fullname: Chen, Jiandong organization: Experimental Therapeutics, H. Lee Moffitt Cancer Center, Tampa, Florida 33612 – sequence: 18 givenname: Wenlong surname: Bai fullname: Bai, Wenlong email: wbai@health.usf.edu organization: Departments of Pathology and Cell Biology, University of South Florida College of Medicine, Tampa, Florida 33612 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19321440$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFks1rGzEQxUVJaZy01x5bHUpvdvW1WulSCHHSFmxcaA2hF6HVztoK3pUjyQn976vEafoBIboIod883sybI3QwhAEQek3JhJJafLhs3GSuCa0rxQh5hkaUKD7mFb04QCNCGB1rVqlDdJTSJSlHaPoCHVLNGRWCjNCP-XTO8InLCU_DzZByBNvj0OFtxbFN2A74jOOZX9kEOAf8NYY-ZMDni4sFXjb-auezH2z2YShsi6ewira9e79Ezzu7SfDq_j5Gy_Oz76efx7PFpy-nJ7Oxk1TlsZSSyEY5RcFqXanOWkeh00S4RrVQy9YKXRNWenQNsRKqRjjBRKPr2nHS8WP0ca-73TU9tA6GHO3GbKPvbfxpgvXm35_Br80qXBsmFVOiLgLv7wViuNpByqb3ycFmYwcIu2RkzQQnTD0JCslqyYh8EmSU6BIfLeCbv70_mP4dUAHEHnAxpBShM87nu_GWVvzGUGJu98CUPTB_9qCUTf4re1B-rODdvmDtV-sbH8E0Prg19KaMqPg1lGt1O6q3e6yzwdhV9Mksv5VoOKGSE1WJQqg9ASXyaw_RJOdhcNAWUZdNG_xjHn4BCwTayw |
| CitedBy_id | crossref_primary_10_1002_jcb_24939 crossref_primary_10_1089_ars_2010_3652 crossref_primary_10_1002_pros_23254 crossref_primary_10_1007_s10555_020_09883_w crossref_primary_10_1038_ncomms12180 crossref_primary_10_1016_j_domaniend_2017_06_002 crossref_primary_10_1371_journal_pone_0086629 crossref_primary_10_1371_journal_pcbi_1005985 crossref_primary_10_1016_j_bbrc_2024_151169 crossref_primary_10_1161_CIRCRESAHA_111_246488 crossref_primary_10_1096_fj_12_212720 crossref_primary_10_1007_s13238_010_0140_9 crossref_primary_10_1016_j_taap_2011_07_016 crossref_primary_10_1136_gutjnl_2015_309322 crossref_primary_10_1016_j_ajpath_2010_10_042 crossref_primary_10_1007_s12253_017_0215_5 crossref_primary_10_1007_s00109_022_02281_5 crossref_primary_10_4251_wjgo_v14_i1_38 crossref_primary_10_1038_cddis_2013_101 crossref_primary_10_1038_ncomms6086 crossref_primary_10_1038_s41467_017_00521_8 crossref_primary_10_1158_1535_7163_MCT_11_0167 crossref_primary_10_1038_onc_2011_35 crossref_primary_10_1016_j_cellsig_2016_03_013 crossref_primary_10_1074_jbc_M115_700047 crossref_primary_10_1093_abbs_gmt147 crossref_primary_10_1152_ajpcell_00142_2011 crossref_primary_10_3390_ijms21124481 crossref_primary_10_3390_antiox11122478 crossref_primary_10_3390_biom12050643 crossref_primary_10_1074_jbc_M109_052845 crossref_primary_10_3858_emm_2011_43_5_032 crossref_primary_10_4161_cam_28437 crossref_primary_10_1002_bies_201700223 crossref_primary_10_3389_fcell_2019_00320 crossref_primary_10_1089_ars_2010_3415 crossref_primary_10_14336_AD_2021_0826 crossref_primary_10_1038_mp_a000945_01 crossref_primary_10_1038_nrm3507 crossref_primary_10_1371_journal_pone_0104444 crossref_primary_10_1038_ncomms2008 crossref_primary_10_1016_j_tranon_2024_101999 crossref_primary_10_1038_onc_2011_277 crossref_primary_10_1111_apha_13003 crossref_primary_10_1186_s13046_021_02057_8 crossref_primary_10_4103_1673_5374_284999 crossref_primary_10_1186_s12967_017_1297_2 crossref_primary_10_1016_j_canlet_2022_215724 crossref_primary_10_1016_j_bbamcr_2011_05_001 crossref_primary_10_1080_15384101_2016_1235848 crossref_primary_10_1152_ajpendo_00467_2015 crossref_primary_10_1111_febs_12669 crossref_primary_10_1101_gad_1941710 crossref_primary_10_1128_JVI_00036_11 crossref_primary_10_1016_j_bbrc_2010_02_051 crossref_primary_10_1186_1752_0509_7_41 crossref_primary_10_5812_jssc_86099 crossref_primary_10_1158_0008_5472_CAN_14_0135 crossref_primary_10_2337_db16_1600 crossref_primary_10_1038_s41419_020_03142_0 crossref_primary_10_1007_s00109_022_02219_x crossref_primary_10_1007_s00421_024_05682_1 crossref_primary_10_3390_ijms242316611 crossref_primary_10_1016_j_biopha_2020_109867 crossref_primary_10_1111_febs_16221 crossref_primary_10_1038_s41598_021_01240_3 crossref_primary_10_4062_biomolther_2022_114 crossref_primary_10_2147_DDDT_S305016 crossref_primary_10_1080_21624054_2015_1103429 crossref_primary_10_1038_srep31240 crossref_primary_10_3389_fnut_2024_1426780 crossref_primary_10_4049_jimmunol_1203247 crossref_primary_10_1158_0008_5472_CAN_17_3512 crossref_primary_10_1158_1535_7163_MCT_19_0045 crossref_primary_10_1093_bioinformatics_btx280 crossref_primary_10_3389_fcell_2019_00114 crossref_primary_10_3390_ijms25042238 crossref_primary_10_1089_jir_2013_0124 crossref_primary_10_1134_S2079057012020129 crossref_primary_10_1111_cas_13619 crossref_primary_10_1007_s40291_015_0153_4 crossref_primary_10_1177_1535370221990322 crossref_primary_10_3892_ijo_2022_5374 crossref_primary_10_1080_21690707_2015_1056906 crossref_primary_10_1007_s10495_015_1097_1 crossref_primary_10_1155_2012_384094 crossref_primary_10_3389_fcvm_2020_585309 crossref_primary_10_1016_j_semcancer_2018_01_004 crossref_primary_10_1083_jcb_201105154 crossref_primary_10_18632_oncotarget_10702 crossref_primary_10_1038_cr_2013_2 crossref_primary_10_1002_1873_3468_13057 crossref_primary_10_1016_j_cellsig_2014_02_022 crossref_primary_10_1016_j_bbamcr_2011_01_007 crossref_primary_10_1002_med_21637 crossref_primary_10_1016_j_canlet_2012_09_017 crossref_primary_10_3390_cells9010184 crossref_primary_10_1002_phy2_28 crossref_primary_10_1186_1741_7007_11_12 crossref_primary_10_1530_ERC_15_0461 crossref_primary_10_3390_biomedicines10071596 crossref_primary_10_1007_s11010_021_04177_3 crossref_primary_10_1016_j_cbi_2014_06_007 crossref_primary_10_1111_jog_14753 crossref_primary_10_1038_s41556_022_00949_1 crossref_primary_10_1089_dna_2022_0449 crossref_primary_10_1038_nrclinonc_2010_174 crossref_primary_10_3892_ijo_2016_3760 crossref_primary_10_1038_ncomms3936 crossref_primary_10_1038_onc_2017_334 crossref_primary_10_1038_s41417_022_00549_z crossref_primary_10_1016_j_molimm_2024_12_001 crossref_primary_10_1038_cddis_2016_225 crossref_primary_10_1016_j_celrep_2023_113098 crossref_primary_10_1002_advs_202000681 crossref_primary_10_1371_journal_pone_0011092 crossref_primary_10_3390_ijms22126314 crossref_primary_10_3389_fcell_2018_00128 crossref_primary_10_1038_s41419_019_1521_5 crossref_primary_10_1074_jbc_M116_715763 crossref_primary_10_1371_journal_pone_0069260 crossref_primary_10_1038_onc_2017_282 crossref_primary_10_1371_journal_pone_0107766 crossref_primary_10_3390_cancers10030078 crossref_primary_10_1093_jmcb_mjr013 crossref_primary_10_1016_j_bpj_2009_11_013 crossref_primary_10_1016_j_abb_2012_07_017 crossref_primary_10_1593_neo_121960 crossref_primary_10_1016_j_bbcan_2018_08_002 crossref_primary_10_1016_j_humpath_2017_02_033 crossref_primary_10_1261_rna_064386_117 crossref_primary_10_1093_toxsci_kfaa185 crossref_primary_10_1016_j_bbamcr_2011_06_002 crossref_primary_10_1016_j_celrep_2019_03_058 crossref_primary_10_1007_s10522_014_9519_y crossref_primary_10_1038_onc_2011_347 crossref_primary_10_1038_onc_2014_377 crossref_primary_10_1053_j_gastro_2014_07_001 crossref_primary_10_3390_cells9092025 |
| Cites_doi | 10.1126/science.1091362 10.1016/S0092-8674(04)00400-3 10.1016/j.cell.2006.12.029 10.1038/sj.emboj.7600045 10.1074/jbc.M207509200 10.1016/j.cmet.2005.08.004 10.1158/0008-5472.CAN-06-0411 10.1128/MCB.21.3.952-965.2001 10.1038/sj.onc.1203980 10.1016/S0092-8674(00)80595-4 10.1038/35008115 10.1016/j.cell.2007.01.003 10.1016/S0168-9525(01)02369-1 10.1128/MCB.23.1.104-118.2003 10.1016/j.cub.2007.01.008 10.1073/pnas.0502738102 10.1073/pnas.0406286101 10.1128/MCB.20.23.8969-8982.2000 10.1210/me.2006-0118 10.1210/me.2004-0292 10.1074/jbc.274.21.15271 10.1073/pnas.0406789102 10.1038/ncb1469 10.1073/pnas.1934283100 10.1074/jbc.M412357200 10.1074/jbc.M213069200 10.1093/emboj/21.9.2263 10.1007/BF03401562 10.1016/j.cell.2005.02.002 10.1128/MCB.22.22.7842-7852.2002 10.1038/sj.emboj.7600791 10.1371/journal.pone.0002819 10.1016/j.tem.2005.03.010 10.1038/387296a0 10.1038/ncb1101-973 10.1038/sj.emboj.7600570 10.1074/jbc.272.36.22966 10.1074/jbc.M404936200 10.1074/jbc.M010226200 10.1023/A:1006133620914 10.1073/pnas.0600889103 10.1038/378203a0 10.1038/nm0297-227 10.1038/ncb1676 10.1016/j.cell.2006.03.046 10.1016/S0092-8674(04)00302-2 10.1093/gerona/60.1.4 10.1093/emboj/cdf406 10.1074/jbc.M102817200 10.1038/sj.emboj.7600476 10.1073/pnas.0405454101 10.1016/S0014-5793(97)01480-4 10.1242/jcs.114.23.4139 10.1126/science.1094637 10.1126/science.1130512 |
| ContentType | Journal Article |
| Copyright | 2009 © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Copyright © 2009, The American Society for Biochemistry and Molecular Biology, Inc. |
| Copyright_xml | – notice: 2009 © 2009 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. – notice: Copyright © 2009, The American Society for Biochemistry and Molecular Biology, Inc. |
| DBID | 6I. AAFTH FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TO H94 7S9 L.6 7X8 5PM |
| DOI | 10.1074/jbc.M901758200 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Oncogenes and Growth Factors Abstracts AIDS and Cancer Research Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Oncogenes and Growth Factors Abstracts AIDS and Cancer Research Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Oncogenes and Growth Factors Abstracts AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1083-351X |
| EndPage | 14000 |
| ExternalDocumentID | PMC2682847 19321440 10_1074_jbc_M901758200 284_21_13987 US201301630854 S0021925820581076 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA093666 – fundername: NCI NIH HHS grantid: R01 CA100302 – fundername: NCI NIH HHS grantid: R01 CA127770 |
| GroupedDBID | --- -DZ -ET -~X .55 0SF 18M 29J 2WC 34G 39C 4.4 53G 5BI 5GY 5RE 5VS 6I. 79B 85S AAEDW AAFTH AAFWJ AARDX AAXUO ABDNZ ABOCM ABPPZ ABRJW ACGFO ACNCT ADBBV ADIYS ADNWM AENEX AEXQZ AFFNX AFMIJ AFOSN AFPKN ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BTFSW C1A CJ0 CS3 DIK DU5 E3Z EBS EJD F20 F5P FDB FRP GROUPED_DOAJ GX1 HH5 HYE IH2 KQ8 L7B MVM N9A OK1 P-O P0W P2P R.V RHF RHI RNS ROL RPM SJN TBC TN5 TR2 UHB UKR UPT VQA W8F WH7 WOQ X7M XFK XSW YQT YSK YWH YZZ ZA5 ZE2 ~02 ~KM .GJ 186 3O- 41~ 6TJ AAYJJ AAYOK ABFSI ABPTK ABTAH ACSFO ACYGS AEQTP AFDAS AI. E.L FA8 FBQ J5H NHB OHT QZG UQL VH1 WHG XJT Y6R YYP ZGI ZY4 - 02 55 AAWZA ABFLS ABUFD ABZEH ADACO ADCOW AEILP AIZTS DL DZ ET FH7 H13 KM LI LI0 MYA O0- X XHC .7T 0R~ AALRI AAYWO AAYXX ACVFH ADCNI ADVLN ADXHL AEUPX AFPUW AIGII AITUG AKBMS AKRWK AKYEP CITATION CGR CUY CVF ECM EIF NPM PKN Z5M 7TO H94 7S9 L.6 7X8 5PM |
| ID | FETCH-LOGICAL-c618t-66606b8c81ea9958faac1ef904cb8de76da49702017cb0a6e5b4c424b977c30f3 |
| ISSN | 0021-9258 |
| IngestDate | Thu Aug 21 18:18:32 EDT 2025 Fri Jul 11 08:08:51 EDT 2025 Fri Jul 11 09:20:20 EDT 2025 Fri Jul 11 00:41:06 EDT 2025 Wed Feb 19 02:29:32 EST 2025 Tue Jul 01 01:53:09 EDT 2025 Thu Apr 24 22:58:21 EDT 2025 Tue Jan 05 14:52:46 EST 2021 Wed Dec 27 19:18:16 EST 2023 Fri Feb 23 02:45:29 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 21 |
| Language | English |
| License | This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0 https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c618t-66606b8c81ea9958faac1ef904cb8de76da49702017cb0a6e5b4c424b977c30f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: Medical College of Georgia Cancer Center, 1120 15th St., CN 2101A, Augusta, GA 30912. This work was supported, in whole or in part, by National Institutes of Health Grants CA93666 (to W. B.) and CA111334 (to W. B.). This work was also supported by Department of Defense Prostate Cancer Grant DAMD17-02-1-0140 (to W. B.) and American Heart Association Predoctoral Fellowship 0315115B (to W. F.). To whom correspondence should be addressed: Dept. of Pathology and Cell Biology, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., MDC 11, Tampa, FL 33612-4799. Fax: 813-974-5536; E-mail: wbai@health.usf.edu. |
| OpenAccessLink | https://dx.doi.org/10.1074/jbc.M901758200 |
| PMID | 19321440 |
| PQID | 21091071 |
| PQPubID | 23462 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2682847 proquest_miscellaneous_67243028 proquest_miscellaneous_46276206 proquest_miscellaneous_21091071 pubmed_primary_19321440 crossref_citationtrail_10_1074_jbc_M901758200 crossref_primary_10_1074_jbc_M901758200 highwire_biochem_284_21_13987 fao_agris_US201301630854 elsevier_sciencedirect_doi_10_1074_jbc_M901758200 |
| ProviderPackageCode | RHF RHI CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-05-22 |
| PublicationDateYYYYMMDD | 2009-05-22 |
| PublicationDate_xml | – month: 05 year: 2009 text: 2009-05-22 day: 22 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The Journal of biological chemistry |
| PublicationTitleAlternate | J Biol Chem |
| PublicationYear | 2009 |
| Publisher | Elsevier Inc American Society for Biochemistry and Molecular Biology |
| Publisher_xml | – name: Elsevier Inc – name: American Society for Biochemistry and Molecular Biology |
| References | Chen, Lin, Levine (bib39) 1995; 1 van der Horst, de Vries-Smits, Brenkman, van Triest, van den Broek, Colland, Maurice, Burgering (bib53) 2006; 8 Yang, Hou, Haller, Nicosia, Bai (bib27) 2005; 24 Sandri, Sandri, Gilbert, Skurk, Calabria, Picard, Walsh, Schiaffino, Lecker, Goldberg (bib8) 2004; 117 Kitamura, Kitamura, Kruse, Raum, Stein, Gu, Accili (bib29) 2005; 2 Li, Nicosia, Bai (bib42) 2001; 276 Macri, Loda (bib59) 1998; 17 Kajihara, Jones, Fusi, Takano, Feroze-Zaidi, Pirianov, Mehmet, Ishihara, Higham, Lam, Brosens (bib7) 2006; 20 Feng, Tamaskovic, Yang, Brazil, Merlo, Hess, Hemmings (bib50) 2004; 279 Haupt, Maya, Kazaz, Oren (bib30) 1997; 387 Tothova, Kollipara, Huntly, Lee, Castrillon, Cullen, McDowell, Lazo-Kallanian, Williams, Sears, Armstrong, Passegue, DePinho, Gilliland (bib14) 2007; 128 Frescas, Valenti, Accili (bib28) 2005; 280 Pochampally, Fodera, Chen, Lu, Chen (bib34) 1999; 274 Li, Lee, Guo, Unterman, Jenster, Bai (bib41) 2003; 23 Lin, Wang, Hu, Altuwaijri, Chang (bib33) 2002; 21 Modur, Nagarajan, Evers, Milbrandt (bib5) 2002; 277 Aoki, Jiang, Vogt (bib15) 2004; 101 Yang, Zong, Xia, Yamaguchi, Ding, Xie, Lang, Lai, Chang, Huang, Huang, Kuo, Lee, Li, Lien, Cheng, Chang, Hsiao, Tsai, Tsai, Sahin, Muller, Mills, Yu, Hortobagyi, Hung (bib47) 2008; 10 Catzavelos, Bhattacharya, Ung, Wilson, Roncari, Sandhu, Shaw, Yeger, Morava-Protzner, Kapusta, Franssen, Pritchard, Slingerland (bib60) 1997; 3 Nakamura, Ramaswamy, Vazquez, Signoretti, Loda, Sellers (bib3) 2000; 20 Huang, Regan, Lou, Chen, Tindall (bib21) 2006; 314 Hu, Lee, Xia, Golfman, Ou-Yang, Yang, Zou, Bao, Hanada, Saso, Kobayashi, Hung (bib20) 2004; 117 Huang, Regan, Wang, Wang, Smith, van Deursen, Tindall (bib46) 2005; 102 Medema, Kops, Bos, Burgering (bib2) 2000; 404 Li, Brooks, Wu-Baer, Chen, Baer, Gu (bib52) 2003; 302 Dong, Chen, Sun, Guo, Vessella, Wang, Chung, Zhou, Dong (bib12) 2006; 66 Kyoung Kim, Kyoung Kim, Song, Baek, Lee, Hye Kim, Kim (bib58) 2005; 60 Jin, Levine (bib54) 2001; 114 Honda, Tanaka, Yasuda (bib43) 1997; 420 McMasters, Montes de Oca Luna, Pena, Lozano (bib37) 1996; 13 Daujat, Neel, Piette (bib45) 2001; 17 Schmidt, Fernandez de Mattos, van der Horst, Klompmaker, Kops, Lam, Burgering, Medema (bib4) 2002; 22 Katoh, Katoh (bib1) 2004; 25 Matsuzaki, Daitoku, Hatta, Tanaka, Fukamizu (bib23) 2003; 100 Perrot, Rechler (bib24) 2005; 19 Montes de Oca Luna, Wagner, Lozano (bib31) 1995; 378 Peng, Chen, Li, Lu, Chen (bib35) 2001; 276 You, Yamamoto, Mak (bib56) 2006; 103 Wang, Ivanov, Chen, Fredericks, Seto, Rauscher, Chen (bib36) 2005; 24 Chen, Marechal, Moreau, Levine, Chen (bib44) 1997; 272 Rena, Woods, Prescott, Peggie, Unterman, Williams, Cohen (bib18) 2002; 21 Yu, Geyer, Maki (bib51) 2000; 19 Brunet, Park, Tran, Hu, Hemmings, Greenberg (bib17) 2001; 21 Carter, Brunet (bib9) 2007; 17 Miyauchi, Minamino, Tateno, Kunieda, Toko, Komuro (bib57) 2004; 23 Paik, Kollipara, Chu, Ji, Xiao, Ding, Miao, Tothova, Horner, Carrasco, Jiang, Gilliland, Chin, Wong, Castrillon, DePinho (bib13) 2007; 128 Chen, Marechal, Levine (bib38) 1993; 13 You, Jang, You-Ten, Okada, Liepa, Wakeham, Zaugg, Mak (bib55) 2004; 101 Brenkman, de Keizer, van den Broek, Jochemsen, Burgering (bib48) 2008; 3 Barthel, Schmoll, Unterman (bib10) 2005; 16 Kenyon (bib11) 2005; 120 Matsuzaki, Daitoku, Hatta, Aoyama, Yoshimochi, Fukamizu (bib25) 2005; 102 Freedman, Levine (bib40) 1999; 59 Brunet, Bonni, Zigmond, Lin, Juo, Hu, Anderson, Arden, Blenis, Greenberg (bib16) 1999; 96 Essers, Weijzen, de Vries-Smits, Saarloos, de Ruiter, Bos, Burgering (bib6) 2004; 23 Plas, Thompson (bib22) 2003; 278 Lehtinen, Yuan, Boag, Yang, Villen, Becker, DiBacco, de la Iglesia, Gygi, Blackwell, Bonni (bib19) 2006; 125 Ganguli, Wasylyk (bib32) 2003; 1 Zhou, Liao, Xia, Zou, Spohn, Hung (bib49) 2001; 3 Brunet, Sweeney, Sturgill, Chua, Greer, Lin, Tran, Ross, Mostoslavsky, Cohen, Hu, Cheng, Jedrychowski, Gygi, Sinclair, Alt, Greenberg (bib26) 2004; 303 Brunet (10.1074/jbc.M901758200_bib16) 1999; 96 You (10.1074/jbc.M901758200_bib55) 2004; 101 Hu (10.1074/jbc.M901758200_bib20) 2004; 117 Honda (10.1074/jbc.M901758200_bib43) 1997; 420 Brunet (10.1074/jbc.M901758200_bib17) 2001; 21 You (10.1074/jbc.M901758200_bib56) 2006; 103 Montes de Oca Luna (10.1074/jbc.M901758200_bib31) 1995; 378 Brenkman (10.1074/jbc.M901758200_bib48) 2008; 3 Katoh (10.1074/jbc.M901758200_bib1) 2004; 25 Perrot (10.1074/jbc.M901758200_bib24) 2005; 19 Modur (10.1074/jbc.M901758200_bib5) 2002; 277 Tothova (10.1074/jbc.M901758200_bib14) 2007; 128 Yu (10.1074/jbc.M901758200_bib51) 2000; 19 Dong (10.1074/jbc.M901758200_bib12) 2006; 66 Schmidt (10.1074/jbc.M901758200_bib4) 2002; 22 Nakamura (10.1074/jbc.M901758200_bib3) 2000; 20 Yang (10.1074/jbc.M901758200_bib27) 2005; 24 Matsuzaki (10.1074/jbc.M901758200_bib23) 2003; 100 Carter (10.1074/jbc.M901758200_bib9) 2007; 17 Haupt (10.1074/jbc.M901758200_bib30) 1997; 387 Chen (10.1074/jbc.M901758200_bib44) 1997; 272 Plas (10.1074/jbc.M901758200_bib22) 2003; 278 Kajihara (10.1074/jbc.M901758200_bib7) 2006; 20 Zhou (10.1074/jbc.M901758200_bib49) 2001; 3 Miyauchi (10.1074/jbc.M901758200_bib57) 2004; 23 Jin (10.1074/jbc.M901758200_bib54) 2001; 114 Wang (10.1074/jbc.M901758200_bib36) 2005; 24 van der Horst (10.1074/jbc.M901758200_bib53) 2006; 8 Peng (10.1074/jbc.M901758200_bib35) 2001; 276 Medema (10.1074/jbc.M901758200_bib2) 2000; 404 Catzavelos (10.1074/jbc.M901758200_bib60) 1997; 3 Freedman (10.1074/jbc.M901758200_bib40) 1999; 59 Li (10.1074/jbc.M901758200_bib41) 2003; 23 Barthel (10.1074/jbc.M901758200_bib10) 2005; 16 Chen (10.1074/jbc.M901758200_bib38) 1993; 13 Huang (10.1074/jbc.M901758200_bib21) 2006; 314 Kyoung Kim (10.1074/jbc.M901758200_bib58) 2005; 60 Lehtinen (10.1074/jbc.M901758200_bib19) 2006; 125 Pochampally (10.1074/jbc.M901758200_bib34) 1999; 274 Matsuzaki (10.1074/jbc.M901758200_bib25) 2005; 102 Sandri (10.1074/jbc.M901758200_bib8) 2004; 117 Brunet (10.1074/jbc.M901758200_bib26) 2004; 303 Essers (10.1074/jbc.M901758200_bib6) 2004; 23 Kitamura (10.1074/jbc.M901758200_bib29) 2005; 2 Feng (10.1074/jbc.M901758200_bib50) 2004; 279 McMasters (10.1074/jbc.M901758200_bib37) 1996; 13 Macri (10.1074/jbc.M901758200_bib59) 1998; 17 Li (10.1074/jbc.M901758200_bib42) 2001; 276 Kenyon (10.1074/jbc.M901758200_bib11) 2005; 120 Lin (10.1074/jbc.M901758200_bib33) 2002; 21 Paik (10.1074/jbc.M901758200_bib13) 2007; 128 Chen (10.1074/jbc.M901758200_bib39) 1995; 1 Huang (10.1074/jbc.M901758200_bib46) 2005; 102 Aoki (10.1074/jbc.M901758200_bib15) 2004; 101 Frescas (10.1074/jbc.M901758200_bib28) 2005; 280 Yang (10.1074/jbc.M901758200_bib47) 2008; 10 Li (10.1074/jbc.M901758200_bib52) 2003; 302 Daujat (10.1074/jbc.M901758200_bib45) 2001; 17 Rena (10.1074/jbc.M901758200_bib18) 2002; 21 Ganguli (10.1074/jbc.M901758200_bib32) 2003; 1 |
| References_xml | – volume: 23 start-page: 104 year: 2003 end-page: 118 ident: bib41 publication-title: Mol. Cell. Biol. – volume: 17 start-page: 459 year: 2001 end-page: 464 ident: bib45 publication-title: Trends Genet. – volume: 17 start-page: 337 year: 1998 end-page: 344 ident: bib59 publication-title: Cancer Metastasis Rev. – volume: 101 start-page: 14057 year: 2004 end-page: 14062 ident: bib55 publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 128 start-page: 325 year: 2007 end-page: 339 ident: bib14 publication-title: Cell – volume: 100 start-page: 11285 year: 2003 end-page: 11290 ident: bib23 publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 13 start-page: 1731 year: 1996 end-page: 1736 ident: bib37 publication-title: Oncogene – volume: 2 start-page: 153 year: 2005 end-page: 163 ident: bib29 publication-title: Cell Metab. – volume: 22 start-page: 7842 year: 2002 end-page: 7852 ident: bib4 publication-title: Mol. Cell. Biol. – volume: 3 start-page: 227 year: 1997 end-page: 230 ident: bib60 publication-title: Nat. Med. – volume: 17 start-page: R113 year: 2007 end-page: R114 ident: bib9 publication-title: Curr. Biol. – volume: 19 start-page: 2283 year: 2005 end-page: 2298 ident: bib24 publication-title: Mol. Endocrinol. – volume: 59 start-page: 1 year: 1999 end-page: 7 ident: bib40 publication-title: Cancer Res. – volume: 420 start-page: 25 year: 1997 end-page: 27 ident: bib43 publication-title: FEBS Lett. – volume: 117 start-page: 399 year: 2004 end-page: 412 ident: bib8 publication-title: Cell – volume: 96 start-page: 857 year: 1999 end-page: 868 ident: bib16 publication-title: Cell – volume: 277 start-page: 47928 year: 2002 end-page: 47937 ident: bib5 publication-title: J. Biol. Chem. – volume: 21 start-page: 2263 year: 2002 end-page: 2271 ident: bib18 publication-title: EMBO J. – volume: 102 start-page: 11278 year: 2005 end-page: 11283 ident: bib25 publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 13 start-page: 4107 year: 1993 end-page: 4114 ident: bib38 publication-title: Mol. Cell. Biol. – volume: 8 start-page: 1064 year: 2006 end-page: 1073 ident: bib53 publication-title: Nat. Cell Biol. – volume: 276 start-page: 40583 year: 2001 end-page: 40590 ident: bib35 publication-title: J. Biol. Chem. – volume: 103 start-page: 9051 year: 2006 end-page: 9056 ident: bib56 publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 404 start-page: 782 year: 2000 end-page: 787 ident: bib2 publication-title: Nature – volume: 274 start-page: 15271 year: 1999 end-page: 15277 ident: bib34 publication-title: J. Biol. Chem. – volume: 1 start-page: 142 year: 1995 end-page: 152 ident: bib39 publication-title: Mol. Med. – volume: 66 start-page: 6998 year: 2006 end-page: 7006 ident: bib12 publication-title: Cancer Res. – volume: 21 start-page: 4037 year: 2002 end-page: 4048 ident: bib33 publication-title: EMBO J. – volume: 19 start-page: 5892 year: 2000 end-page: 5897 ident: bib51 publication-title: Oncogene – volume: 387 start-page: 296 year: 1997 end-page: 299 ident: bib30 publication-title: Nature – volume: 117 start-page: 225 year: 2004 end-page: 237 ident: bib20 publication-title: Cell – volume: 302 start-page: 1972 year: 2003 end-page: 1975 ident: bib52 publication-title: Science – volume: 114 start-page: 4139 year: 2001 end-page: 4140 ident: bib54 publication-title: J. Cell Sci. – volume: 21 start-page: 952 year: 2001 end-page: 965 ident: bib17 publication-title: Mol. Cell. Biol. – volume: 3 start-page: e2819 year: 2008 ident: bib48 publication-title: PLoS ONE – volume: 125 start-page: 987 year: 2006 end-page: 1001 ident: bib19 publication-title: Cell – volume: 278 start-page: 12361 year: 2003 end-page: 12366 ident: bib22 publication-title: J. Biol. Chem. – volume: 378 start-page: 203 year: 1995 end-page: 206 ident: bib31 publication-title: Nature – volume: 16 start-page: 183 year: 2005 end-page: 189 ident: bib10 publication-title: Trends Endocrinol. Metab. – volume: 303 start-page: 2011 year: 2004 end-page: 2015 ident: bib26 publication-title: Science – volume: 20 start-page: 8969 year: 2000 end-page: 8982 ident: bib3 publication-title: Mol. Cell. Biol. – volume: 120 start-page: 449 year: 2005 end-page: 460 ident: bib11 publication-title: Cell – volume: 102 start-page: 1649 year: 2005 end-page: 1654 ident: bib46 publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 60 start-page: 4 year: 2005 end-page: 9 ident: bib58 publication-title: J. Gerontol. A Biol. Sci. Med. Sci. – volume: 314 start-page: 294 year: 2006 end-page: 297 ident: bib21 publication-title: Science – volume: 1 start-page: 1027 year: 2003 end-page: 1035 ident: bib32 publication-title: Mol. Cancer Res. – volume: 23 start-page: 4802 year: 2004 end-page: 4812 ident: bib6 publication-title: EMBO J. – volume: 25 start-page: 1495 year: 2004 end-page: 1500 ident: bib1 publication-title: Int. J. Oncol. – volume: 10 start-page: 138 year: 2008 end-page: 148 ident: bib47 publication-title: Nat. Cell Biol. – volume: 3 start-page: 973 year: 2001 end-page: 982 ident: bib49 publication-title: Nat. Cell Biol. – volume: 128 start-page: 309 year: 2007 end-page: 323 ident: bib13 publication-title: Cell – volume: 24 start-page: 3279 year: 2005 end-page: 3290 ident: bib36 publication-title: EMBO J. – volume: 24 start-page: 1021 year: 2005 end-page: 1032 ident: bib27 publication-title: EMBO J. – volume: 279 start-page: 35510 year: 2004 end-page: 35517 ident: bib50 publication-title: J. Biol. Chem. – volume: 276 start-page: 20444 year: 2001 end-page: 20450 ident: bib42 publication-title: J. Biol. Chem. – volume: 280 start-page: 20589 year: 2005 end-page: 20595 ident: bib28 publication-title: J. Biol. Chem. – volume: 101 start-page: 13613 year: 2004 end-page: 13617 ident: bib15 publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 20 start-page: 2444 year: 2006 end-page: 2455 ident: bib7 publication-title: Mol. Endocrinol. – volume: 272 start-page: 22966 year: 1997 end-page: 22973 ident: bib44 publication-title: J. Biol. Chem. – volume: 23 start-page: 212 year: 2004 end-page: 220 ident: bib57 publication-title: EMBO J. – volume: 13 start-page: 4107 year: 1993 ident: 10.1074/jbc.M901758200_bib38 publication-title: Mol. Cell. Biol. – volume: 302 start-page: 1972 year: 2003 ident: 10.1074/jbc.M901758200_bib52 publication-title: Science doi: 10.1126/science.1091362 – volume: 117 start-page: 399 year: 2004 ident: 10.1074/jbc.M901758200_bib8 publication-title: Cell doi: 10.1016/S0092-8674(04)00400-3 – volume: 128 start-page: 309 year: 2007 ident: 10.1074/jbc.M901758200_bib13 publication-title: Cell doi: 10.1016/j.cell.2006.12.029 – volume: 23 start-page: 212 year: 2004 ident: 10.1074/jbc.M901758200_bib57 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600045 – volume: 277 start-page: 47928 year: 2002 ident: 10.1074/jbc.M901758200_bib5 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M207509200 – volume: 2 start-page: 153 year: 2005 ident: 10.1074/jbc.M901758200_bib29 publication-title: Cell Metab. doi: 10.1016/j.cmet.2005.08.004 – volume: 66 start-page: 6998 year: 2006 ident: 10.1074/jbc.M901758200_bib12 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-0411 – volume: 21 start-page: 952 year: 2001 ident: 10.1074/jbc.M901758200_bib17 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.3.952-965.2001 – volume: 13 start-page: 1731 year: 1996 ident: 10.1074/jbc.M901758200_bib37 publication-title: Oncogene – volume: 19 start-page: 5892 year: 2000 ident: 10.1074/jbc.M901758200_bib51 publication-title: Oncogene doi: 10.1038/sj.onc.1203980 – volume: 96 start-page: 857 year: 1999 ident: 10.1074/jbc.M901758200_bib16 publication-title: Cell doi: 10.1016/S0092-8674(00)80595-4 – volume: 404 start-page: 782 year: 2000 ident: 10.1074/jbc.M901758200_bib2 publication-title: Nature doi: 10.1038/35008115 – volume: 128 start-page: 325 year: 2007 ident: 10.1074/jbc.M901758200_bib14 publication-title: Cell doi: 10.1016/j.cell.2007.01.003 – volume: 17 start-page: 459 year: 2001 ident: 10.1074/jbc.M901758200_bib45 publication-title: Trends Genet. doi: 10.1016/S0168-9525(01)02369-1 – volume: 23 start-page: 104 year: 2003 ident: 10.1074/jbc.M901758200_bib41 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.1.104-118.2003 – volume: 17 start-page: R113 year: 2007 ident: 10.1074/jbc.M901758200_bib9 publication-title: Curr. Biol. doi: 10.1016/j.cub.2007.01.008 – volume: 102 start-page: 11278 year: 2005 ident: 10.1074/jbc.M901758200_bib25 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0502738102 – volume: 101 start-page: 14057 year: 2004 ident: 10.1074/jbc.M901758200_bib55 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0406286101 – volume: 20 start-page: 8969 year: 2000 ident: 10.1074/jbc.M901758200_bib3 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.20.23.8969-8982.2000 – volume: 20 start-page: 2444 year: 2006 ident: 10.1074/jbc.M901758200_bib7 publication-title: Mol. Endocrinol. doi: 10.1210/me.2006-0118 – volume: 19 start-page: 2283 year: 2005 ident: 10.1074/jbc.M901758200_bib24 publication-title: Mol. Endocrinol. doi: 10.1210/me.2004-0292 – volume: 274 start-page: 15271 year: 1999 ident: 10.1074/jbc.M901758200_bib34 publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.21.15271 – volume: 102 start-page: 1649 year: 2005 ident: 10.1074/jbc.M901758200_bib46 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0406789102 – volume: 8 start-page: 1064 year: 2006 ident: 10.1074/jbc.M901758200_bib53 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1469 – volume: 100 start-page: 11285 year: 2003 ident: 10.1074/jbc.M901758200_bib23 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1934283100 – volume: 280 start-page: 20589 year: 2005 ident: 10.1074/jbc.M901758200_bib28 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M412357200 – volume: 278 start-page: 12361 year: 2003 ident: 10.1074/jbc.M901758200_bib22 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M213069200 – volume: 21 start-page: 2263 year: 2002 ident: 10.1074/jbc.M901758200_bib18 publication-title: EMBO J. doi: 10.1093/emboj/21.9.2263 – volume: 1 start-page: 142 year: 1995 ident: 10.1074/jbc.M901758200_bib39 publication-title: Mol. Med. doi: 10.1007/BF03401562 – volume: 120 start-page: 449 year: 2005 ident: 10.1074/jbc.M901758200_bib11 publication-title: Cell doi: 10.1016/j.cell.2005.02.002 – volume: 22 start-page: 7842 year: 2002 ident: 10.1074/jbc.M901758200_bib4 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.22.7842-7852.2002 – volume: 24 start-page: 3279 year: 2005 ident: 10.1074/jbc.M901758200_bib36 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600791 – volume: 25 start-page: 1495 year: 2004 ident: 10.1074/jbc.M901758200_bib1 publication-title: Int. J. Oncol. – volume: 3 start-page: e2819 year: 2008 ident: 10.1074/jbc.M901758200_bib48 publication-title: PLoS ONE doi: 10.1371/journal.pone.0002819 – volume: 16 start-page: 183 year: 2005 ident: 10.1074/jbc.M901758200_bib10 publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2005.03.010 – volume: 387 start-page: 296 year: 1997 ident: 10.1074/jbc.M901758200_bib30 publication-title: Nature doi: 10.1038/387296a0 – volume: 3 start-page: 973 year: 2001 ident: 10.1074/jbc.M901758200_bib49 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1101-973 – volume: 24 start-page: 1021 year: 2005 ident: 10.1074/jbc.M901758200_bib27 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600570 – volume: 1 start-page: 1027 year: 2003 ident: 10.1074/jbc.M901758200_bib32 publication-title: Mol. Cancer Res. – volume: 272 start-page: 22966 year: 1997 ident: 10.1074/jbc.M901758200_bib44 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.36.22966 – volume: 279 start-page: 35510 year: 2004 ident: 10.1074/jbc.M901758200_bib50 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M404936200 – volume: 276 start-page: 20444 year: 2001 ident: 10.1074/jbc.M901758200_bib42 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010226200 – volume: 17 start-page: 337 year: 1998 ident: 10.1074/jbc.M901758200_bib59 publication-title: Cancer Metastasis Rev. doi: 10.1023/A:1006133620914 – volume: 103 start-page: 9051 year: 2006 ident: 10.1074/jbc.M901758200_bib56 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0600889103 – volume: 378 start-page: 203 year: 1995 ident: 10.1074/jbc.M901758200_bib31 publication-title: Nature doi: 10.1038/378203a0 – volume: 3 start-page: 227 year: 1997 ident: 10.1074/jbc.M901758200_bib60 publication-title: Nat. Med. doi: 10.1038/nm0297-227 – volume: 10 start-page: 138 year: 2008 ident: 10.1074/jbc.M901758200_bib47 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1676 – volume: 125 start-page: 987 year: 2006 ident: 10.1074/jbc.M901758200_bib19 publication-title: Cell doi: 10.1016/j.cell.2006.03.046 – volume: 59 start-page: 1 year: 1999 ident: 10.1074/jbc.M901758200_bib40 publication-title: Cancer Res. – volume: 117 start-page: 225 year: 2004 ident: 10.1074/jbc.M901758200_bib20 publication-title: Cell doi: 10.1016/S0092-8674(04)00302-2 – volume: 60 start-page: 4 year: 2005 ident: 10.1074/jbc.M901758200_bib58 publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/60.1.4 – volume: 21 start-page: 4037 year: 2002 ident: 10.1074/jbc.M901758200_bib33 publication-title: EMBO J. doi: 10.1093/emboj/cdf406 – volume: 276 start-page: 40583 year: 2001 ident: 10.1074/jbc.M901758200_bib35 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M102817200 – volume: 23 start-page: 4802 year: 2004 ident: 10.1074/jbc.M901758200_bib6 publication-title: EMBO J. doi: 10.1038/sj.emboj.7600476 – volume: 101 start-page: 13613 year: 2004 ident: 10.1074/jbc.M901758200_bib15 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0405454101 – volume: 420 start-page: 25 year: 1997 ident: 10.1074/jbc.M901758200_bib43 publication-title: FEBS Lett. doi: 10.1016/S0014-5793(97)01480-4 – volume: 114 start-page: 4139 year: 2001 ident: 10.1074/jbc.M901758200_bib54 publication-title: J. Cell Sci. doi: 10.1242/jcs.114.23.4139 – volume: 303 start-page: 2011 year: 2004 ident: 10.1074/jbc.M901758200_bib26 publication-title: Science doi: 10.1126/science.1094637 – volume: 314 start-page: 294 year: 2006 ident: 10.1074/jbc.M901758200_bib21 publication-title: Science doi: 10.1126/science.1130512 |
| SSID | ssj0000491 |
| Score | 2.3724244 |
| Snippet | Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO... Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO... Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO... |
| SourceID | pubmedcentral proquest pubmed crossref highwire fao elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 13987 |
| SubjectTerms | Animals Apoptosis Cell Line Cell Nucleus - metabolism Cytoprotection Forkhead Transcription Factors - metabolism Gene Expression Regulation Humans Mechanisms of Signal Transduction Mice Phosphorylation Protein Binding Protein Processing, Post-Translational Protein Transport Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - metabolism Tumor Suppressor Protein p53 - metabolism Ubiquitin-Protein Ligases - metabolism Ubiquitination |
| Title | MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation |
| URI | https://dx.doi.org/10.1074/jbc.M901758200 http://www.jbc.org/content/284/21/13987.abstract https://www.ncbi.nlm.nih.gov/pubmed/19321440 https://www.proquest.com/docview/21091071 https://www.proquest.com/docview/46276206 https://www.proquest.com/docview/67243028 https://pubmed.ncbi.nlm.nih.gov/PMC2682847 |
| Volume | 284 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLa6cYALgg1YgYEPCA5VR-I4v25Mo9UE7aqJVqq4WHbilKAtKTQ5wF_Pe3HStGMVPy5R5b60ab_P9nv28_cIeaUtFiruyD7MZqzPE4hZgyQJ4RJIZkeJyxQeTh5feOcz_mHuzjudd5unSwp1Ev289VzJ_6AKbYArnpL9B2TXHwoN8BrwhSsgDNe_wnj8fsxQDWPVi3GRGJPGr6sUZtfB-jHQdQdO7ypdwEyFPuaySr3TveFkPumVKv1WpkVqVgOrPYQYhSPiFqqvLZM2_FYj22SERZpqcWsWlFXOnk7bhW5suEzLZTNFVqkEZqwbtXaj1CQLZ4ukbmxWIkLcRGebi5NVugczUuzN6MpMBbiaRuY0dD1YgvNpJtvfhnHwa3AYV9HJGPwVCGmMnOkNveyLiRjORiMxHcyne-QOg0ABa1h8vGz14iH-MTUT6ydrZDt9_nb703e5JXuJzDe0o2-LQ26m0274J9MH5H4NED01LHlIOjo7IIenAG9-_YO-plWqb7WHckDunjXAHZLPSCKKJKItiWieUCARlSsqMzpwqCERLXJak4giieg2icA2phskekRmw8H07LxfF9zoR54dFNBfIZxVQRTYWoahGyRSRrZOQotHKoi178WShz4EGLYfKUt62lU84owrCCIix0qcx2Q_yzN9RGjouVpbSsOkAQG-chVjisV4v1Zu6LIu6Tf_t4hqNXosinIlqqwInwvAR7T4dMmbtf3S6LDstLQb-ETtRRrvUAC7dt5zBDgLuYCJVcw-MdzOh0AFwhHeJccN-AI6GHYsAZwWzBYVf7vkZcMIAcjhdpvMdF6uwAJ9cd_ebcE9Br6I5e228HzGHQgBuuSJ4Vj740MsMcbh0f0t9q0NUDd--50s_VLpxzMvQKf06R-_9Rm51_bz52S_-F7qY_DBC_Wi6ma_AG3C2S4 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MDM2+acts+downstream+of+p53+as+an+E3+ligase+to+promote+FOXO+ubiquitination+and+degradation&rft.jtitle=The+Journal+of+biological+chemistry&rft.au=Fu%2C+Wei&rft.au=Ma%2C+Qiuping&rft.au=Chen%2C+Lei&rft.au=Li%2C+Pengfei&rft.date=2009-05-22&rft.issn=0021-9258&rft.volume=284&rft.issue=21&rft.spage=13987&rft_id=info:doi/10.1074%2Fjbc.M901758200&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9258&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9258&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9258&client=summon |