Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood–brain barrier integrity

• Published in: Molecular psychiatry Vol. 19; no. 10; pp. 1143 - 1149
• Main Authors: Hammer, C, Stepniak, B, Schneider, A, Papiol, S, Tantra, M, Begemann, M, Sirén, A-L, Pardo, L A, Sperling, S, Mohd Jofrry, S, Gurvich, A, Jensen, N, Ostmeier, K, Lühder, F, Probst, C, Martens, H, Gillis, M, Saher, G, Assogna, F, Spalletta, G, Stöcker, W, Schulz, T F, Nave, K-A, Ehrenreich, H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2014; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/250/38; 631/378/1341; 692/699/476/377; Adult; Aged; Analysis; Animals; Apolipoprotein E; Apolipoproteins E - genetics; Apolipoproteins E - metabolism; Autoantibodies; Autoantibodies - blood; Behavioral Sciences; Biological Psychology; Blood & organ donations; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain research; Cerebral Cortex - metabolism; Clinical significance; Cognitive ability; Diagnosis; Disease; Dizocilpine; Encephalitis; Endocytosis; Endocytosis - physiology; Epilepsy; Extrapyramidal system; Female; Genetic aspects; Genetic diversity; Genome-Wide Association Study; Genomes; Glutamic acid receptors; Glutamic acid receptors (ionotropic); Humans; Immunoglobulins; Influenza; Influenza A; Influenza, Human - genetics; Influenza, Human - metabolism; Male; Medicine; Medicine & Public Health; Mental disorders; Mental illness; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mood Disorders - genetics; Mood Disorders - metabolism; N-Methyl-D-aspartic acid receptors; Neurons - metabolism; Neurosciences; original-article; Parkinson Disease - genetics; Parkinson Disease - metabolism; Patients; Pharmacotherapy; Physiological aspects; Polymorphism, Single Nucleotide; Prevalence studies (Epidemiology); Psychiatry; Psychosis; Receptors, N-Methyl-D-Aspartate - genetics; Receptors, N-Methyl-D-Aspartate - immunology; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Serology; Trauma; Germany; influenza; GWAS; ApoE null mutant mice; autoimmunity

In 2007, a multifaceted syndrome, associated with anti-NMDA receptor autoantibodies (NMDAR-AB) of immunoglobulin-G isotype, has been described, which variably consists of psychosis, epilepsy, cognitive decline and extrapyramidal symptoms. Prevalence and significance of NMDAR-AB in complex neuropsych...