Pre-diagnostic anti-EBV antibodies and primary liver cancer risk: a population-based nested case-control study in southern China

• Published in: BMC cancer Vol. 23; no. 1; pp. 250 - 9
• Main Authors: Du, Yun, Yu, Xia, Chang, Ellen T., Lian, Shifeng, Wu, Biaohua, Li, Fugui, Chu, Bing, Wei, Kuangrong, Zhan, Jiyun, Liang, Xuejun, Ye, Weimin, Ji, Mingfang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.03.2023; BioMed Central; BMC
• Subjects: Antibodies; Antibodies, Viral; Antibody; Antigens; Antigens, Viral; Biomarkers; Capsid Proteins; Case-Control Studies; China - epidemiology; Epidemiology; Epstein-Barr virus; Epstein-Barr Virus Infections; Health aspects; Hepatitis B; Hepatitis B surface antigen; Hepatitis B Surface Antigens; Herpesvirus 4, Human; Humans; Identification and classification; Immunoglobulin A; Infections; Liver cancer; Liver Neoplasms - complications; Liver Neoplasms - diagnosis; Liver Neoplasms - epidemiology; Lymphoma; Males; Measurement; Medical diagnosis; Medical screening; Nasopharyngeal Neoplasms - diagnosis; Nested case-control study; Optical density; Population studies; Population-based; Population-based studies; Primary liver cancer; Risk factors; Sensitivity analysis; Serology; China; Population-based; Epstein-Barr virus; Primary liver cancer; Nested case-control study; Antibody; Epidemiology
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-023-10709-5

We aimed to investigate associations between pre-diagnostic anti-Epstein-Barr virus (EBV) antibodies, including interactions with hepatitis B virus (HBV), and risk of primary liver cancer in southern China. In a population-based nested case-control study, we measured pre-diagnostic immunoglobulin A...