Agonist-selective signaling is determined by the receptor location within the membrane domains - Zheng, Hui; Chu, Ji; Qiu, Yu; Loh, Horace H; Law, Ping-Yee (Proceedings of the National Academy of Sciences - PNAS, 2008)
Keywords: adenylate cyclase; Agonists; Animals; Antibodies; Arrestins - metabolism; beta-Arrestins; beta-Cyclodextrins - pharmacology; Binding sites; Biological Sciences; Cell Line; Cell membranes; Cholesterols; Colforsin - pharmacology; dissociation; etorphine; Etorphine - pharmacology; Gene Deletion; GTP-Binding Protein alpha Subunit, Gi2 - metabolism; guanosine triphosphate; HEK293 cells; Humans; hydrolysis; Lipids; Male; Membrane Microdomains - drug effects; Membrane Microdomains - metabolism; Membranes; Mice; Mice, Inbred C57BL; Microscopy, Confocal; mitogen-activated protein kinase; Morphine; Morphine - pharmacology; Mutant Proteins - metabolism; Phosphorylation; Protein Binding - drug effects; Protein Transport - drug effects; Proteins; Rafts; Receptors; Receptors, Opioid, mu - agonists; Signal transduction; Signal Transduction - drug effects; Translocation