Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion

• Published in: Oncoimmunology Vol. 8; no. 11; p. 1657374
• Main Authors: Tripathi, Reshmi, Modur, Vishnu, Senovilla, Laura, Kroemer, Guido, Komurov, Kakajan
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.11.2019; Taylor & Francis Group
• Subjects: Cancer; cancer aneuploidy; Chromosomal Instability; Immunology; immunoselection; Life Sciences; Medicin och hälsovetenskap; Original Research; TCGA; immunoselection; Chromosomal Instability; TCGA; cancer aneuploidy

Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human tumors with high chromosomal instability (CIN+) are significantly less immunogenic, as judged by tumor lymphocyte infiltration, compared to...