Inhibitory Effects of a Novel Antiplatelet Agent, E5510, on Collagen-Induced Platelet-Derived Growth Factor Release and Aggregation of Human Platelets In Vitro

• Published in: Japanese Journal of Pharmacology Vol. 61; no. 1; pp. 7 - 12
• Main Authors: Nomoto, Ken-ichi, Saeki, Takao, Kogushi, Motoji, Kobayashi, Hiroko, Fujimori, Tohru, Yamatsu, Isao
• Format: Journal Article
• Language: English; Japanese
• Published: Kyoto The Japanese Pharmacological Society 1993; Japanese Pharmacological Society
• Subjects: aggregation; Animals; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood. Blood coagulation. Reticuloendothelial system; Cell Division - drug effects; Cell proliferation; Cells, Cultured; collagen; Collagen - pharmacology; E5510; effects on; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Monounsaturated - pharmacology; Humans; induction; man; Medical sciences; Muscle, Smooth - cytology; Muscle, Smooth - drug effects; Pharmacology. Drug treatments; Platelet (human); Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - pharmacology; Platelet-derived growth factor; Platelet-Derived Growth Factor - metabolism; platelets; Radioimmunoassay; Rats; Rats, Sprague-Dawley; release; Smooth muscle cell; Smooth muscle cell; Cell proliferation; E5510; Platelet-derived growth factor; Platelet (human); Aggregation; Human; Platelet; Mechanism of action; In vitro; Platelet derived growth factor; Antiplatelet agent; Release

E5510, 4-cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid, is a new anti-platelet-aggregation agent under development. We examined the inhibitory efficacy of E5510 on PDGF-release from washed human platelets. E5510 concentration-dependently inhibited collagen-induced PDGF release from human platelets...