Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo

• Published in: Nature communications Vol. 11; no. 1; pp. 5417 - 12
• Main Authors: Richard Albert, Julien, Au Yeung, Wan Kin, Toriyama, Keisuke, Kobayashi, Hisato, Hirasawa, Ryutaro, Brind’Amour, Julie, Bogutz, Aaron, Sasaki, Hiroyuki, Lorincz, Matthew
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.10.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 14/35; 38/39; 38/91; 45/15; 45/23; 631/136/2086; 631/208/176/1968; 631/208/176/1988; 631/208/200; 631/337/176/1988; 64/60; Alleles; Blastocysts; CpG islands; Deoxyribonucleic acid; Developmental stages; DNA; DNA methylation; Embryos; Epigenetics; Fertilization; Gene deletion; Gene expression; Gene sequencing; Gene silencing; Genomes; Humanities and Social Sciences; Life Sciences; Loci; Mass spectrometry; Mass spectroscopy; multidisciplinary; Promoters; Science; Science (multidisciplinary); Spermatogenesis

De novo DNA methylation (DNAme) during mammalian spermatogenesis yields a densely methylated genome, with the exception of CpG islands (CGIs), which are hypomethylated in sperm. While the paternal genome undergoes widespread DNAme loss before the first S-phase following fertilization, recent mass sp...