Unexplored therapeutic opportunities in the human genome

• Published in: Nature reviews. Drug discovery Vol. 17; no. 5; pp. 317 - 332
• Main Authors: Oprea, Tudor I., Bologa, Cristian G., Brunak, Søren, Campbell, Allen, Gan, Gregory N., Gaulton, Anna, Gomez, Shawn M., Guha, Rajarshi, Hersey, Anne, Holmes, Jayme, Jadhav, Ajit, Jensen, Lars Juhl, Johnson, Gary L., Karlson, Anneli, Leach, Andrew R., Ma'ayan, Avi, Malovannaya, Anna, Mani, Subramani, Mathias, Stephen L., McManus, Michael T., Meehan, Terrence F., von Mering, Christian, Muthas, Daniel, Nguyen, Dac-Trung, Overington, John P., Papadatos, George, Qin, Jun, Reich, Christian, Roth, Bryan L., Schürer, Stephan C., Simeonov, Anton, Sklar, Larry A., Southall, Noel, Tomita, Susumu, Tudose, Ilinca, Ursu, Oleg, Vidović, Dušica, Waller, Anna, Westergaard, David, Yang, Jeremy J., Zahoránszky-Köhalmi, Gergely
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2018; Nature Publishing Group
• Subjects: 631/154/555; 631/154/556; 692/308/153; analysis; association; Biomedical research; Biomedicine; Biotechnology; Cancer Research; Cellular proteins; drug discovery; Drug metabolism; druggable genome; expression; genetic; Genetic aspects; Genomes; Knowledge management; large-scale; ligands; Medical Genetics; Medicinal Chemistry; Medicinsk genetik; Molecular Medicine; orphan nuclear receptors; Pharmacological research; Pharmacology/Toxicology; protein-degradation; Proteins; Proteomics; schizophrenia; target identification; Testing

In 2014, the Illuminating the Druggable Genome programme was launched to promote the exploration of currently understudied but potentially druggable proteins. This article discusses how the systematic collection and processing of a wide array of biological and chemical data as part of this programme...