Cross-species analysis traces adaptation of Rubisco toward optimality in a low-dimensional landscape

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 8; pp. 3475 - 3480
• Main Authors: Savir, Yonatan, Noor, Elad, Milo, Ron, Tlusty, Tsvi
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.02.2010; National Acad Sciences
• Subjects: Algae; autotrophs; Bacteria - enzymology; Biochemistry; Biological Sciences; Biosphere; carbon; Carbon dioxide; Carbon Dioxide - metabolism; Carbon fixation; Carboxylation; Enzyme kinetics; Enzymes; Eukaryota - enzymology; Evolution; Evolution, Molecular; Kinetics; Molecules; Oxygen; Photosynthesis; Plants; Plants - enzymology; Power laws; proteins; ribulose-bisphosphate carboxylase; Ribulose-Bisphosphate Carboxylase - chemistry; Ribulose-Bisphosphate Carboxylase - metabolism; Species Specificity; Substrate Specificity; Velocity

Rubisco (D-ribulose 1,5-bisphosphate carboxylase/oxygenase), probably the most abundant protein in the biosphere, performs an essential part in the process of carbon fixation through photosynthesis, thus facilitating life on earth. Despite the significant effect that Rubisco has on the fitness of pl...