Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling - Mekhoubad, Shila; Bock, Christoph; de Boer, A. Sophie; Kiskinis, Evangelos; Meissner, Alexander; Eggan, Kevin (Cell stem cell, 2012)
Keywords: anthropogenic activities; Biological and medical sciences; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Cells, Cultured; Chromosomes, Human, X - genetics; DNA Methylation; Dosage Compensation, Genetic; epigenetics; Female; females; Fundamental and applied biological sciences. Psychology; genes; Genomic Instability; Histones - metabolism; Humans; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; Lesch-Nyhan Syndrome - genetics; Lesch-Nyhan Syndrome - pathology; Lesch-Nyhan Syndrome - physiopathology; Models, Biological; Molecular and cellular biology; RNA, Long Noncoding; RNA, Untranslated - genetics; somatic cells; stem cells; transcription (genetics); X chromosome; Human; Gene dosage; Dosage compensation; Modeling