Notch1 functions as a tumor suppressor in mouse skin

• Published in: Nature genetics Vol. 33; no. 3; pp. 416 - 421
• Main Authors: Wolfer, Anita, Radtke, Freddy, Nicolas, Michael, Dotto, G. Paolo, Kummer, J. Alain, Mill, Pleasantine, Clevers, Hans, van Noort, Mascha, Hui, Chi-chung, Raj, Kenneth
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2003; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Animals; beta Catenin; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer cells; Cancer Research; Carcinogenesis; Cellular signal transduction; Classical genetics, quantitative genetics, hybrids; Cytoskeletal Proteins - metabolism; DNA-Binding Proteins - metabolism; Embryos; Epidermis; Fundamental and applied biological sciences. Psychology; Gene Function; Genes, Tumor Suppressor; Genetic aspects; Genetics of eukaryotes. Biological and molecular evolution; Human Genetics; Inactivation; Keratinocytes - transplantation; Kruppel-Like Transcription Factors; letter; Lymphoid Enhancer-Binding Factor 1; Mammals; Membrane Proteins - deficiency; Membrane Proteins - genetics; Membrane Proteins - physiology; Mice; Mice, Knockout; Mice, Nude; Mice, Transgenic; Physiological aspects; Physiology; Receptor, Notch1; Receptors, Cell Surface; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction; Skin; Skin - metabolism; Skin - pathology; Skin Neoplasms - genetics; Skin Neoplasms - pathology; Skin Neoplasms - prevention & control; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor suppressor genes; Tumors; Vertebrata; Zinc Finger Protein Gli2; United States; Vertebrata; Mammalia; Mouse; Rodentia; Suppressor; Tumor; Skin

Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is associated with tumorigenesis. The role of Notch signaling in mammalian skin is less well characterized and is mainly based on in vitro studies, wh...