D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients

• Published in: The international journal of neuropsychopharmacology Vol. 22; no. 7; pp. 415 - 425
• Main Authors: Stenkrona, Per, Matheson, Granville J, Halldin, Christer, Cervenka, Simon, Farde, Lars
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2019
• Subjects: Adult; Antipsychotic agents; Antipsychotics; Bayesian analysis; Benzazepines; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain Mapping; Brain research; Cardiotonic agents; D-1 dopamine receptor; Diagnostic imaging; Dopamine; dorsolateral prefrontal cortex; drug naive; Female; Follow-Up Studies; Health aspects; Humans; Hypotheses; Magnetic Resonance Imaging; Male; Medical research; Middle Aged; Phenols (Class of compounds); Physiological aspects; Positron emission tomography; Psychosis; Psychotic disorders; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - metabolism; Radiopharmaceuticals; Receptors, Dopamine D1 - metabolism; Regular s; Schizophrenia; Schizophrenia - diagnostic imaging; Schizophrenia - metabolism; Tomography; Young Adult; Sweden; D1 dopamine receptor; schizophrenia; positron emission tomography; dorsolateral prefrontal cortex; drug naïve

Positron emission tomography studies examining differences in D1-dopamine receptor binding between control subjects and patients with schizophrenia have been inconsistent, reporting higher, lower, and no difference in the frontal cortex. Exposure to antipsychotic medication has been suggested to be...