YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

• Published in: Nature cell biology Vol. 11; no. 12; pp. 1444 - 1450
• Main Authors: Overholtzer, Michael, Smolen, Gromoslaw A, Brugge, Joan S, Zhang, Jianmin, Ji, Jun-Yuan, Yu, Min, Dyson, Nicholas J, Haber, Daniel A, Wang, Rebecca
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2009; Nature Publishing Group
• Subjects: Amphiregulin; Animals; Biomedical and Life Sciences; Cancer cells; Cancer Research; Carcinogenesis; Causes of; Cell Biology; Cell Cycle Proteins; Cell growth; Cell Line, Tumor; Cellular signal transduction; Developmental Biology; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; EGF Family of Proteins; Epidermal growth factor; ErbB Receptors - genetics; ErbB Receptors - metabolism; Female; Genetic aspects; Glycoproteins - genetics; Glycoproteins - metabolism; Health aspects; Humans; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Kinases; letter; Life Sciences; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Physiological aspects; Physiology; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proteins; Receptors, Invertebrate Peptide - metabolism; Signal Transduction; Stem Cells; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; YAP-Signaling Proteins; United States; United States > US

The Hippo signalling pathway regulates cellular proliferation and survival, thus has profound effects on normal cell fate and tumorigenesis. The pivotal effector of this pathway is YAP (yes-associated protein), a transcriptional co-activator amplified in mouse and human cancers, where it promotes ep...