Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

Objective: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. Methods, design and measureme...

Full description

Saved in:
Bibliographic Details
Published inInternational Journal of Obesity Vol. 36; no. 11; pp. 1442 - 1449
Main Authors Moreno-Navarrete, J M, Ortega, F, Serino, M, Luche, E, Waget, A, Pardo, G, Salvador, J, Ricart, W, Frühbeck, G, Burcelin, R, Fernández-Real, J M
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2012
Nature Publishing Group
Subjects
631/45/287/1190
692/53
692/699/2743/393
692/699/317
Acute-Phase Proteins - metabolism
Adipose Tissue
Analysis
Animals
Binding proteins
Biological and medical sciences
Biomarkers - blood
Blood
Body Mass Index
Carrier Proteins - blood
Complications and side effects
Cross-Sectional Studies
Diabetes
Diet
Endocrinology
Enzyme-Linked Immunosorbent Assay
Epidemiology
Female
Glucagon
Glucose
Health Promotion and Disease Prevention
Humans
Immune system
Inflammation - blood
Insulin Resistance
Internal Medicine
Lipids
Male
Medical sciences
Medicine
Medicine & Public Health
Membrane Glycoproteins - blood
Metabolic Diseases
Metabolism
Mice
Nutrition research
Obesity
Obesity - blood
original-article
Peptides
Physiological aspects
Plasma
Proteins
Public Health
Risk factors
Spain
Systemic diseases
Weight control
Weight Loss
White people
Spain
insulin resistance
LPS
LBP
Endocrinopathy
Human
Obesity
Pancreatic hormone
Nutrition
Rodentia
Nutrition disorder
Biological marker
Metabolic diseases
Protein A
Insulin
Binding protein
Target tissue resistance
Vertebrata
Mammalia
Mouse
Lipopolysaccharide
Insulin resistance
Nutritional status
Online AccessGet full text
ISSN0307-0565
1476-5497
1476-5497
DOI10.1038/ijo.2011.256

Cover

Abstract Objective: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. Methods, design and measurements: We studied the cross-sectional ( n =222) and weight loss-induced ( n =34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. Results: Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2±5.8 vs 16.2±9.3 μg ml −1 , P <0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. Conclusion: LBP is an inflammatory marker associated with obesity-related insulin resistance.
AbstractList OBJECTIVE: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n = 222) and weight loss-induced (n = 34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. RESULTS: Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ±9.3 µg[ml.sup.-1], P<0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. CONCLUSION: LBP is an inflammatory marker associated with obesity-related insulin resistance. International Journal of Obesity (2012) 36, 1442-1449; doi:10.1038/ijo.2011.256; published online 20 December 2011 Keywords: LBP;LPS;insulin resistance
Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 μg ml(-1), P<0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. LBP is an inflammatory marker associated with obesity-related insulin resistance.
Objective: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. Methods, design and measurements: We studied the cross-sectional ( n =222) and weight loss-induced ( n =34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. Results: Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2±5.8 vs 16.2±9.3 μg ml −1 , P <0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. Conclusion: LBP is an inflammatory marker associated with obesity-related insulin resistance.
International Journal of Obesity (2012) 36, 1442-1449; doi:10.1038/ijo.2011.256; published online 20 December 2011
Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice.OBJECTIVELipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice.Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 μg ml(-1), P<0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration.RESULTSCirculating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 μg ml(-1), P<0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration.LBP is an inflammatory marker associated with obesity-related insulin resistance.CONCLUSIONLBP is an inflammatory marker associated with obesity-related insulin resistance.
Objective: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice.Methods, design and measurements:We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. Results: Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 plus or minus 5.8 vs 16.2 plus or minus 9.3 mu g ml super(-1), P<0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. Conclusion: LBP is an inflammatory marker associated with obesity-related insulin resistance.
Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed to gain insights into the association of circulating LBP with insulin resistance in humans and mice. METHODS, DESIGN AND MEASUREMENTS: We studied the cross-sectional (n=222) and weight loss-induced (n=34) associations of LBP (enzyme-linked immunosorbent assay) with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity), and the effects of high-fat diet (HFD), metformin and genetic insulin sensitization (glucagon-like peptide 1 receptor knockout model) in mice. Circulating LBP concentration was significantly increased in subjects with type 2 diabetes and dramatically increased in subjects with morbid obesity. LBP was significantly associated with insulin sensitivity and different inflammatory markers and decreased after weight loss (22.2 ± 5.8 vs 16.2 ± 9.3 μgml(-1), P<0.0001) in association with changes in body mass index and insulin sensitivity. Circulating LBP concentration was increased in HFD mice, whereas decreased in glucagon-like peptide 1 receptor knockout mice (significantly more insulin sensitive than wild-type mice) and after metformin administration. LBP is an inflammatory marker associated with obesity-related insulin resistance.
Audience Academic
Author Luche, E
Pardo, G
Burcelin, R
Serino, M
Frühbeck, G
Fernández-Real, J M
Moreno-Navarrete, J M
Waget, A
Ortega, F
Salvador, J
Ricart, W
Author_xml – sequence: 1
  givenname: J M
  surname: Moreno-Navarrete
  fullname: Moreno-Navarrete, J M
  organization: Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII)
– sequence: 2
  givenname: F
  surname: Ortega
  fullname: Ortega, F
  organization: Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII)
– sequence: 3
  givenname: M
  surname: Serino
  fullname: Serino, M
  organization: Unité Mixte de Recherche (UMR), Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil
– sequence: 4
  givenname: E
  surname: Luche
  fullname: Luche, E
  organization: Unité Mixte de Recherche (UMR), Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil
– sequence: 5
  givenname: A
  surname: Waget
  fullname: Waget, A
  organization: Unité Mixte de Recherche (UMR), Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil
– sequence: 6
  givenname: G
  surname: Pardo
  fullname: Pardo, G
  organization: Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII)
– sequence: 7
  givenname: J
  surname: Salvador
  fullname: Salvador, J
  organization: Department of Endocrinology and Metabolic Research Laboratory, Clínica Universitaria de Navarra, CIBEROBN (CB06/03/1014) and Instituto de Salud Carlos III (ISCIII)
– sequence: 8
  givenname: W
  surname: Ricart
  fullname: Ricart, W
  organization: Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII)
– sequence: 9
  givenname: G
  surname: Frühbeck
  fullname: Frühbeck, G
  organization: Department of Endocrinology and Metabolic Research Laboratory, Clínica Universitaria de Navarra, CIBEROBN (CB06/03/1014) and Instituto de Salud Carlos III (ISCIII)
– sequence: 10
  givenname: R
  surname: Burcelin
  fullname: Burcelin, R
  organization: Unité Mixte de Recherche (UMR), Institut de Medecine Moleculaire de Rangueil, Institut National de la Santé et de la Recherche Médicale U858, IFR31, Centre Hospitalier Universitaire Rangueil
– sequence: 11
  givenname: J M
  surname: Fernández-Real
  fullname: Fernández-Real, J M
  email: jmfernandezreal.girona.ics@gencat.cat
  organization: Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII)
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26580758$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22184060$$D View this record in MEDLINE/PubMed
BookMark eNqF0kuP0zAQAOAILWIfcOOMIiHQIpEyfsROjkvFS6oEBzhHrjNuXVy7ayeH_nscWtiHFqEcEjnfjGY8c16c-OCxKJ4TmBFgzTu7CTMKhMxoLR4VZ4RLUdW8lSfFGTCQFdSiPi3OU9oAQF0DfVKcUkoaDgLOCjO3UY9ODdavSmd3YRfcPimt1yraHqul9f30axfDgNaXl4v3396UKpWq3Kr4E2MZTBmWmOywryLmRNiX1qfRZRzzcRqU1_i0eGyUS_js-L4ofnz88H3-uVp8_fRlfrWotCByqLhm9bLnkpiWGoCWI9FcMNkgY1Q2ogdkUjLQ0HBUJn-xHsGQWpgMmWAXxeUhb673esQ0dFubNDqnPIYxdYRTCcCJbP9PSU1ayiltMn15j27CGH1u5LdinPKW3qiVcthZb8IQlZ6SdlcM2rYBwUhWswdUfnrcWp1Ha2w-vxPw-lbAGpUb1im4cbDBp7vwxbHKcbnFvttFm0e07_4MO4NXR6CSVs7EPBmbbpyoG5D11O7bg9MxpBTR_CUEumnnurxz3bRzXd65zOk9ru2gpvJyZ9b9K6g6BKWc268w3rrSh_wvBe7jyg
CODEN IJOBDP
CitedBy_id crossref_primary_10_3389_fnut_2024_1393292
crossref_primary_10_1016_j_micpath_2020_104276
crossref_primary_10_1080_15384101_2023_2169521
crossref_primary_10_1016_j_jnutbio_2019_03_003
crossref_primary_10_1038_ijo_2016_32
crossref_primary_10_1038_s41366_021_01039_2
crossref_primary_10_1007_s13679_019_00352_2
crossref_primary_10_1016_j_isci_2020_101777
crossref_primary_10_1186_s12610_016_0034_7
crossref_primary_10_14336_AD_2017_0630
crossref_primary_10_1016_j_biopha_2018_09_165
crossref_primary_10_1111_apt_13327
crossref_primary_10_1111_1469_0691_12170
crossref_primary_10_1210_jc_2013_3327
crossref_primary_10_1038_s41467_024_47553_5
crossref_primary_10_1016_j_jep_2016_10_043
crossref_primary_10_51249_hs_v2i01_661
crossref_primary_10_1016_j_atherosclerosis_2013_07_004
crossref_primary_10_1038_s41575_022_00685_9
crossref_primary_10_3390_ph18020279
crossref_primary_10_1002_ddr_21092
crossref_primary_10_1016_j_canlet_2017_12_001
crossref_primary_10_1093_jac_dku032
crossref_primary_10_1097_MD_0000000000022442
crossref_primary_10_1016_j_isci_2024_109779
crossref_primary_10_1016_j_soard_2014_11_030
crossref_primary_10_1038_s41396_018_0064_6
crossref_primary_10_1038_s41598_020_78493_x
crossref_primary_10_1053_j_gastro_2019_06_048
crossref_primary_10_1007_s12603_016_0725_y
crossref_primary_10_1007_s11154_019_09523_x
crossref_primary_10_1051_medsci_20163205012
crossref_primary_10_1002_oby_21711
crossref_primary_10_1016_S2213_8587_14_70134_2
crossref_primary_10_1111_jgh_13488
crossref_primary_10_1017_S0007114516004086
crossref_primary_10_1111_1753_0407_12281
crossref_primary_10_1016_j_jff_2017_12_050
crossref_primary_10_1177_09612033211050321
crossref_primary_10_1111_eci_14224
crossref_primary_10_1007_s10552_016_0783_9
crossref_primary_10_1016_j_atherosclerosis_2015_04_814
crossref_primary_10_1038_s41598_017_12109_9
crossref_primary_10_3389_fmicb_2015_01151
crossref_primary_10_1016_j_metabol_2018_04_004
crossref_primary_10_1007_s10875_021_01120_5
crossref_primary_10_3390_nu13020289
crossref_primary_10_1186_s13073_021_00851_9
crossref_primary_10_3389_fimmu_2021_681810
crossref_primary_10_1111_1574_6941_12228
crossref_primary_10_1039_D4FO01650E
crossref_primary_10_3390_nu13020558
crossref_primary_10_1051_jbio_2017008
crossref_primary_10_1371_journal_pone_0207882
crossref_primary_10_1161_JAHA_119_013628
crossref_primary_10_1371_journal_pone_0170028
crossref_primary_10_1007_s11605_020_04694_4
crossref_primary_10_4093_dmj_2017_41_6_466
crossref_primary_10_1038_s42003_021_02753_3
crossref_primary_10_3390_cells10010071
crossref_primary_10_1002_biof_1457
crossref_primary_10_3390_idr17010010
crossref_primary_10_3390_nu15102277
crossref_primary_10_3390_metabo13020250
crossref_primary_10_1186_s40168_024_01901_1
crossref_primary_10_1371_journal_pone_0252936
crossref_primary_10_3390_ijms222312846
crossref_primary_10_1097_MCG_0000000000000363
crossref_primary_10_12938_bmfh_2021_061
crossref_primary_10_2337_dc15_1777
crossref_primary_10_1007_s40257_022_00724_w
crossref_primary_10_1007_s00125_016_4028_y
crossref_primary_10_1007_s00394_019_02117_y
crossref_primary_10_2217_bmm_2018_0198
crossref_primary_10_1016_j_cca_2018_07_042
crossref_primary_10_1371_journal_pone_0222598
crossref_primary_10_1016_j_soard_2018_03_033
crossref_primary_10_3920_BM2016_0230
crossref_primary_10_1016_j_jff_2019_103688
crossref_primary_10_14309_ajg_0000000000000511
crossref_primary_10_1016_j_molmet_2016_05_016
crossref_primary_10_14218_ERHM_2020_00037
crossref_primary_10_3389_fimmu_2018_02918
crossref_primary_10_3945_an_115_010587
crossref_primary_10_1016_j_cdnut_2022_100023
crossref_primary_10_1016_j_clnu_2020_08_036
crossref_primary_10_1136_bmjopen_2017_015910
crossref_primary_10_1089_met_2014_1504
crossref_primary_10_3389_fphys_2021_712694
crossref_primary_10_3390_fermentation10120643
crossref_primary_10_1016_j_cnd_2014_12_001
crossref_primary_10_3389_fimmu_2015_00223
crossref_primary_10_1007_s00221_023_06763_x
crossref_primary_10_1007_s11357_016_9924_z
crossref_primary_10_3390_cancers14174075
crossref_primary_10_1080_01635581_2024_2367266
crossref_primary_10_1016_j_nutres_2018_03_014
crossref_primary_10_1038_s41598_020_79241_x
crossref_primary_10_1002_mnfr_201800160
crossref_primary_10_1007_s00394_015_0900_7
crossref_primary_10_1016_j_diabres_2018_07_003
crossref_primary_10_3389_fimmu_2023_1117742
crossref_primary_10_3390_jcm12072451
crossref_primary_10_1016_j_humgen_2023_201158
crossref_primary_10_1371_journal_pone_0145337
crossref_primary_10_3390_nu11030652
crossref_primary_10_1007_s11892_015_0634_1
crossref_primary_10_1002_path_5134
crossref_primary_10_1007_s13340_020_00428_8
crossref_primary_10_1186_s13098_018_0360_3
crossref_primary_10_1007_s11695_018_3242_8
crossref_primary_10_1016_j_soard_2014_02_022
crossref_primary_10_1111_obr_12068
crossref_primary_10_3389_fendo_2023_1173481
crossref_primary_10_1016_j_jnutbio_2022_109242
crossref_primary_10_3109_09513590_2014_994602
crossref_primary_10_1053_j_gastro_2014_02_008
crossref_primary_10_1507_endocrj_EJ18_0446
crossref_primary_10_3389_fendo_2021_628907
crossref_primary_10_1038_ismej_2014_45
crossref_primary_10_1016_j_omtn_2022_01_002
crossref_primary_10_3345_kjp_2016_59_5_231
crossref_primary_10_1038_ismej_2012_153
crossref_primary_10_1080_21623945_2024_2374062
crossref_primary_10_4236_ojped_2021_112022
crossref_primary_10_1007_s11357_019_00112_z
crossref_primary_10_1016_j_atherosclerosis_2014_06_022
crossref_primary_10_1177_09727531221108849
crossref_primary_10_1186_s13098_021_00655_2
crossref_primary_10_1016_j_hnm_2024_200286
crossref_primary_10_1016_j_biopha_2022_113156
crossref_primary_10_3109_10408363_2015_1123215
crossref_primary_10_3945_ajcn_112_057331
crossref_primary_10_1016_j_omtn_2022_08_003
crossref_primary_10_3389_fnut_2021_754222
crossref_primary_10_1007_s11695_018_3518_z
crossref_primary_10_1111_jre_12081
crossref_primary_10_1002_prca_201800173
crossref_primary_10_1016_j_jnutbio_2012_10_002
crossref_primary_10_3390_microorganisms7090320
crossref_primary_10_52927_jdcr_2023_11_2_61
crossref_primary_10_1016_j_molmet_2020_100997
crossref_primary_10_1093_jn_nxx027
crossref_primary_10_1111_1574_6941_12250
crossref_primary_10_1136_bmjdrc_2020_001386
crossref_primary_10_1530_JME_16_0054
crossref_primary_10_1002_mnfr_201500102
crossref_primary_10_1186_s12933_017_0545_3
crossref_primary_10_3390_metabo13080952
crossref_primary_10_14814_phy2_14199
crossref_primary_10_1016_j_smim_2017_06_002
crossref_primary_10_1038_ijo_2017_162
crossref_primary_10_1111_eci_12997
crossref_primary_10_1186_s13098_023_01137_3
crossref_primary_10_1586_1744666X_2014_911088
crossref_primary_10_1017_S000711451300024X
crossref_primary_10_1177_1535370219900185
crossref_primary_10_1016_j_beem_2021_101507
crossref_primary_10_1128_spectrum_01466_23
crossref_primary_10_3389_fmolb_2024_1458675
crossref_primary_10_2188_jea_JE20220232
crossref_primary_10_1038_s41598_018_33928_4
crossref_primary_10_1007_s00125_013_3015_9
crossref_primary_10_1002_1873_3468_14328
Cites_doi 10.1182/blood.V98.13.3800
10.2337/db07-1403
10.1084/jem.180.3.1025
10.1016/j.bbrc.2006.05.170
10.1084/jem.179.1.269
10.1172/JCI200319246
10.2337/diabetes.47.11.1757
10.1161/01.CIR.102.1.42
10.2337/diabetes.55.01.06.db05-1108
10.1111/j.1365-2672.2010.04922.x
10.2337/db06-1491
10.2337/db09-0700
10.2337/dc05-2068
10.1172/JCI112886
10.2337/dc09-1392
10.1007/s001250051058
10.1016/j.micinf.2005.10.006
10.1210/jc.2007-0349
10.2337/db08-0121
10.1161/01.CIR.0000055014.62083.05
10.3945/jn.108.092346
10.1016/j.jacc.2007.02.070
10.2337/dc10-0340
10.1210/er.2002-0010
10.1161/01.ATV.0000122852.22604.78
10.1016/S0021-9258(17)37218-6
10.1016/S0021-9258(18)81700-8
10.1016/S1016-8478(23)12877-9
ContentType Journal Article
Copyright Macmillan Publishers Limited 2012
2014 INIST-CNRS
COPYRIGHT 2012 Nature Publishing Group
Copyright Nature Publishing Group Nov 2012
Copyright_xml – notice: Macmillan Publishers Limited 2012
– notice: 2014 INIST-CNRS
– notice: COPYRIGHT 2012 Nature Publishing Group
– notice: Copyright Nature Publishing Group Nov 2012
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T2
7TK
7TS
7X2
7X7
7XB
88E
88G
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0K
M0S
M1P
M2M
M7P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PSYQQ
Q9U
7X8
DOI 10.1038/ijo.2011.256
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health and Safety Science Abstracts (Full archive)
Neurosciences Abstracts
Physical Education Index
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
ProQuest Pharma Collection
Public Health Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Agricultural Science Database
Health & Medical Collection (Alumni)
Medical Database
ProQuest - Psychology Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
ProQuest Central Basic
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
ProQuest One Psychology
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
Physical Education Index
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Agricultural & Environmental Science Collection
Biological Science Collection
Health & Safety Science Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Public Health
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Psychology Journals (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest Psychology Journals
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE


MEDLINE - Academic

Physical Education Index
Agricultural Science Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Public Health
Diet & Clinical Nutrition
Recreation & Sports
EISSN 1476-5497
EndPage 1449
ExternalDocumentID 2814039191
A309980631
22184060
26580758
10_1038_ijo_2011_256
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Spain
GeographicLocations_xml – name: Spain
GroupedDBID .55
.GJ
29J
36B
39C
5RE
7X2
7X7
8R4
8R5
A8Z
ABDBF
ABOCM
ABUWG
ACUHS
ADBBV
AFFNX
AI.
ALMA_UNASSIGNED_HOLDINGS
ATCPS
AZQEC
B0M
BAWUL
BENPR
BHPHI
BPHCQ
DIK
DWQXO
EAD
EAP
EBC
EBD
EBS
EMB
EMK
EMOBN
EPL
ESX
F5P
FYUFA
GNUQQ
HCIFZ
IAO
IHR
ITC
J5H
M0K
M1P
M2M
MVM
NAO
OK1
Q2X
RNT
RNTTT
SV3
TUS
VH1
WH7
X7M
ZGI
ZXP
~8M
AAYXX
CITATION
IQODW
---
-Q-
..I
.L3
.XZ
0R~
1CY
2FS
2WC
4.4
406
53G
5GY
70F
88E
8AO
8C1
8FE
8FH
8FI
8FJ
AACDK
AAHBH
AANZL
AASML
AATNV
AAWTL
AAYZH
ABAKF
ABAWZ
ABCQX
ABDBE
ABIVO
ABJNI
ABLJU
ABZZP
ACAOD
ACGFS
ACKTT
ACPRK
ACRQY
ACZOJ
ADHUB
AEFQL
AEJRE
AEMSY
AENEX
AEUYN
AEVLU
AEXYK
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALIPV
AMYLF
APEBS
AXYYD
AYFIA
BBNVY
BKKNO
BVXVI
CCPQU
CGR
CS3
CUY
CVF
DNIVK
DPUIP
DU5
E3Z
EBLON
ECM
EE.
EIF
EIOEI
EJD
FDQFY
FERAY
FIGPU
FIZPM
FSGXE
HMCUK
HZ~
IHW
INH
INR
IPY
IWAJR
JSO
JZLTJ
KQ8
L7B
M7P
NPM
NQJWS
O9-
OVD
P2P
P6G
PHGZT
PQQKQ
PROAC
PSQYO
PSYQQ
RNS
ROL
SNX
SNYQT
SOHCF
SOJ
SRMVM
SWTZT
TAOOD
TBHMF
TDRGL
TEORI
TR2
TSG
UKHRP
YCJ
~KM
3V.
7T2
7TK
7TS
7XB
8FK
C1K
K9.
LK8
PHGZM
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
7X8
ABBRH
ABFSG
ACSTC
AEZWR
AFDZB
AFHIU
AHWEU
AIXLP
ATHPR
ID FETCH-LOGICAL-c617t-4c35bd471f92f0094e1c46378e332786d0e37730c084eaf7303de0f156f1c4363
IEDL.DBID 7X7
ISSN 0307-0565
1476-5497
IngestDate Fri Jul 11 07:13:09 EDT 2025
Thu Jul 10 16:46:35 EDT 2025
Thu Jul 17 02:13:20 EDT 2025
Tue Jun 17 21:01:56 EDT 2025
Tue Jun 10 20:27:45 EDT 2025
Thu May 22 21:21:53 EDT 2025
Thu Apr 03 06:58:25 EDT 2025
Mon Jul 21 09:15:29 EDT 2025
Tue Jul 01 03:01:49 EDT 2025
Thu Apr 24 22:53:55 EDT 2025
Fri Feb 21 02:39:38 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords insulin resistance
LPS
LBP
Endocrinopathy
Human
Obesity
Pancreatic hormone
Nutrition
Rodentia
Nutrition disorder
Biological marker
Metabolic diseases
Protein A
Insulin
Binding protein
Target tissue resistance
Vertebrata
Mammalia
Mouse
Lipopolysaccharide
Insulin resistance
Nutritional status
Language English
License http://www.springer.com/tdm
CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c617t-4c35bd471f92f0094e1c46378e332786d0e37730c084eaf7303de0f156f1c4363
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
PMID 22184060
PQID 1151342492
PQPubID 38864
PageCount 8
ParticipantIDs proquest_miscellaneous_1427004179
proquest_miscellaneous_1151924228
proquest_journals_1151342492
gale_infotracmisc_A309980631
gale_infotracacademiconefile_A309980631
gale_healthsolutions_A309980631
pubmed_primary_22184060
pascalfrancis_primary_26580758
crossref_primary_10_1038_ijo_2011_256
crossref_citationtrail_10_1038_ijo_2011_256
springer_journals_10_1038_ijo_2011_256
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2012-11-01
PublicationDateYYYYMMDD 2012-11-01
PublicationDate_xml – month: 11
  year: 2012
  text: 2012-11-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: Basingstoke
– name: England
PublicationTitle International Journal of Obesity
PublicationTitleAbbrev Int J Obes
PublicationTitleAlternate Int J Obes (Lond)
PublicationYear 2012
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Cani, Amar, Iglesias, Poggi, Knauf, Bastelica (CR20) 2007; 56
Naito, Yoshida, Makino, Kounoshi, Kunihiro, Takahashi (CR25) 2011; 110
Fernandez-Real, Ricart (CR5) 2003; 24
Ceriello, Motz (CR9) 2004; 24
Ouellet, Weisnagel, Marois, Bergeron, Julien, Gougeon (CR27) 2008; 138
Fernández-Real, López-Bermejo, Vendrell, Ferri, Recasens, Ricart (CR8) 2006; 29
Mente, Razak, Blankenberg, Vuksan, Davis, Miller (CR28) 2010; 33
Gubern, Lopez-Bermejo, Biarnes, Vendrell, Ricart, Fernandez-Real (CR14) 2006; 55
Sun, Yu, Ye, Zou, Li, Yu (CR16) 2010; 33
Bergman, Prager, Volund, Olefsky (CR17) 1987; 79
Hailman, Lichenstein, Wurfel, Miller, Johnson, Kelley (CR12) 1994; 179
Moreno-Navarrete, Martínez-Barricarte, Catalán, Sabater, Gómez-Ambrosi, Ortega (CR18) 2010; 59
Fernández-Real, Broch, Ricart, Casamitjana, Gutierrez, Vendrell (CR26) 1998; 47
Grube, Cochane, Ye, Green, McPhail, Ulevitch (CR10) 1994; 269
Gómez-Ambrosi, Catalán, Ramírez, Rodríguez, Colina, Silva (CR19) 2007; 92
Cabou, Campistron, Marsollier, Leloup, Cruciani-Guglielmacci, Pénicaud (CR21) 2008; 57
Song, Kim, Yoon, Kim (CR7) 2006; 346
Tobias, Soldau, Ulevitch (CR11) 1989; 264
Wurfel, Kunitake, Lichenstein, Kane, Wright (CR13) 1994; 180
Pickup, Crook (CR2) 1998; 41
Festa, D’Agostino, Howard, Mykkänen, Tracy, Haffner (CR3) 2000; 102
Zweigner, Gramm, Singer, Wegscheider, Schumann (CR24) 2001; 98
Lepper, Schumann, Triantafilou, Rasche, Schuster, Frank (CR15) 2007; 50
Ridker, Buring, Cook, Rifai (CR4) 2003; 107
Lee, Hwang (CR6) 2006; 21
Weisberg, McCann, Desai, Rosenbaum, Leibel, Ferrante (CR1) 2003; 112
Cani, Bibiloni, Knauf, Waget, Neyrinck, Delzenne (CR22) 2008; 57
Zweigner, Schumann, Weber (CR23) 2006; 8
JM Fernández-Real (BFijo2011256_CR8) 2006; 29
BJ Grube (BFijo2011256_CR10) 1994; 269
MM Wurfel (BFijo2011256_CR13) 1994; 180
PM Lepper (BFijo2011256_CR15) 2007; 50
JM Fernández-Real (BFijo2011256_CR26) 1998; 47
V Ouellet (BFijo2011256_CR27) 2008; 138
RN Bergman (BFijo2011256_CR17) 1987; 79
E Naito (BFijo2011256_CR25) 2011; 110
A Mente (BFijo2011256_CR28) 2010; 33
SP Weisberg (BFijo2011256_CR1) 2003; 112
PD Cani (BFijo2011256_CR22) 2008; 57
J Zweigner (BFijo2011256_CR24) 2001; 98
MJ Song (BFijo2011256_CR7) 2006; 346
L Sun (BFijo2011256_CR16) 2010; 33
JM Fernandez-Real (BFijo2011256_CR5) 2003; 24
PM Ridker (BFijo2011256_CR4) 2003; 107
E Hailman (BFijo2011256_CR12) 1994; 179
C Cabou (BFijo2011256_CR21) 2008; 57
JC Pickup (BFijo2011256_CR2) 1998; 41
PS Tobias (BFijo2011256_CR11) 1989; 264
JY Lee (BFijo2011256_CR6) 2006; 21
JM Moreno-Navarrete (BFijo2011256_CR18) 2010; 59
J Zweigner (BFijo2011256_CR23) 2006; 8
A Ceriello (BFijo2011256_CR9) 2004; 24
C Gubern (BFijo2011256_CR14) 2006; 55
A Festa (BFijo2011256_CR3) 2000; 102
J Gómez-Ambrosi (BFijo2011256_CR19) 2007; 92
PD Cani (BFijo2011256_CR20) 2007; 56
References_xml – volume: 98
  start-page: 3800
  year: 2001
  end-page: 3808
  ident: CR24
  article-title: High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes
  publication-title: Blood
  doi: 10.1182/blood.V98.13.3800
– volume: 269
  start-page: 8477
  year: 1994
  end-page: 8482
  ident: CR10
  article-title: Lipopolysaccharide binding protein expression in primary human hepatocytes and HepG2 hepatoma cells
  publication-title: J Biol Chem
– volume: 57
  start-page: 1470
  year: 2008
  end-page: 1481
  ident: CR22
  article-title: Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
  publication-title: Diabetes
  doi: 10.2337/db07-1403
– volume: 180
  start-page: 1025
  year: 1994
  end-page: 1035
  ident: CR13
  article-title: Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS
  publication-title: J Exp Med
  doi: 10.1084/jem.180.3.1025
– volume: 346
  start-page: 739
  year: 2006
  end-page: 745
  ident: CR7
  article-title: Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2006.05.170
– volume: 179
  start-page: 269
  year: 1994
  end-page: 277
  ident: CR12
  article-title: Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
  publication-title: J Exp Med
  doi: 10.1084/jem.179.1.269
– volume: 112
  start-page: 1796
  year: 2003
  end-page: 1808
  ident: CR1
  article-title: Obesity is associated with macrophage accumulation in adipose tissue
  publication-title: J Clin Invest
  doi: 10.1172/JCI200319246
– volume: 47
  start-page: 1757
  year: 1998
  end-page: 1762
  ident: CR26
  article-title: Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance
  publication-title: Diabetes
  doi: 10.2337/diabetes.47.11.1757
– volume: 102
  start-page: 42
  year: 2000
  end-page: 47
  ident: CR3
  article-title: Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
  publication-title: Circulation
  doi: 10.1161/01.CIR.102.1.42
– volume: 55
  start-page: 216
  year: 2006
  end-page: 224
  ident: CR14
  article-title: Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein
  publication-title: Diabetes
  doi: 10.2337/diabetes.55.01.06.db05-1108
– volume: 110
  start-page: 650
  year: 2011
  end-page: 657
  ident: CR25
  article-title: Benefitial effect of oral administration of strain Shirota on insulin resistance in diet-induced obesity mice
  publication-title: J Appl Microbiol
  doi: 10.1111/j.1365-2672.2010.04922.x
– volume: 56
  start-page: 1761
  year: 2007
  end-page: 1772
  ident: CR20
  article-title: Metabolic endotoxemia initiates obesity and insulin resistance
  publication-title: Diabetes
  doi: 10.2337/db06-1491
– volume: 59
  start-page: 200
  year: 2010
  end-page: 209
  ident: CR18
  article-title: Complement factor H is expressed in adipose tissue in association with insulin resistance
  publication-title: Diabetes
  doi: 10.2337/db09-0700
– volume: 29
  start-page: 1058
  year: 2006
  end-page: 1064
  ident: CR8
  article-title: Burden of infection and insulin resistance in healthy middle-aged men
  publication-title: Diabetes Care
  doi: 10.2337/dc05-2068
– volume: 79
  start-page: 790
  year: 1987
  end-page: 800
  ident: CR17
  article-title: Equivalence of the insulin sensitivity index in man derived by the minimal model method and euglycaemic glucose clamp
  publication-title: J Clin Invest
  doi: 10.1172/JCI112886
– volume: 33
  start-page: 1629
  year: 2010
  end-page: 1634
  ident: CR28
  article-title: Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance
  publication-title: Diabetes Care
  doi: 10.2337/dc09-1392
– volume: 21
  start-page: 174
  year: 2006
  end-page: 185
  ident: CR6
  article-title: The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors
  publication-title: Mol Cell
– volume: 41
  start-page: 1241
  year: 1998
  end-page: 1248
  ident: CR2
  article-title: Is type II diabetes mellitus a disease of the innate immune system?
  publication-title: Diabetologia
  doi: 10.1007/s001250051058
– volume: 8
  start-page: 946
  year: 2006
  end-page: 952
  ident: CR23
  article-title: The role of lipopolysaccharide-binding protein in modulating the innate immune response
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2005.10.006
– volume: 92
  start-page: 3719
  year: 2007
  end-page: 3727
  ident: CR19
  article-title: Plasma osteopontin levels and expresión in adipose tissue in obesity
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2007-0349
– volume: 57
  start-page: 2577
  year: 2008
  end-page: 2587
  ident: CR21
  article-title: Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity
  publication-title: Diabetes
  doi: 10.2337/db08-0121
– volume: 107
  start-page: 391
  year: 2003
  end-page: 397
  ident: CR4
  article-title: C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000055014.62083.05
– volume: 138
  start-page: 2386
  year: 2008
  end-page: 2391
  ident: CR27
  article-title: Dietary cod protein reduces plasma C-reactive protein in insulin-resistant men and women
  publication-title: J Nutr
  doi: 10.3945/jn.108.092346
– volume: 264
  start-page: 10867
  year: 1989
  end-page: 10871
  ident: CR11
  article-title: Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein
  publication-title: J Biol Chem
– volume: 50
  start-page: 25
  year: 2007
  end-page: 31
  ident: CR15
  article-title: Association of lipopolysaccharide-binding protein and coronary artery disease in men
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2007.02.070
– volume: 33
  start-page: 1925
  year: 2010
  end-page: 1932
  ident: CR16
  article-title: A marker of endotoxemia is associated with obesity and related disorders in apparently healthy Chinese
  publication-title: Diabetes Care
  doi: 10.2337/dc10-0340
– volume: 24
  start-page: 278
  year: 2003
  end-page: 301
  ident: CR5
  article-title: Insulin resistance and chronic cardiovascular inflammatory syndrome
  publication-title: Endocr Rev
  doi: 10.1210/er.2002-0010
– volume: 24
  start-page: 816
  year: 2004
  end-page: 823
  ident: CR9
  article-title: Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000122852.22604.78
– volume: 57
  start-page: 2577
  year: 2008
  ident: BFijo2011256_CR21
  publication-title: Diabetes
  doi: 10.2337/db08-0121
– volume: 56
  start-page: 1761
  year: 2007
  ident: BFijo2011256_CR20
  publication-title: Diabetes
  doi: 10.2337/db06-1491
– volume: 138
  start-page: 2386
  year: 2008
  ident: BFijo2011256_CR27
  publication-title: J Nutr
  doi: 10.3945/jn.108.092346
– volume: 57
  start-page: 1470
  year: 2008
  ident: BFijo2011256_CR22
  publication-title: Diabetes
  doi: 10.2337/db07-1403
– volume: 92
  start-page: 3719
  year: 2007
  ident: BFijo2011256_CR19
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2007-0349
– volume: 50
  start-page: 25
  year: 2007
  ident: BFijo2011256_CR15
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2007.02.070
– volume: 24
  start-page: 278
  year: 2003
  ident: BFijo2011256_CR5
  publication-title: Endocr Rev
  doi: 10.1210/er.2002-0010
– volume: 102
  start-page: 42
  year: 2000
  ident: BFijo2011256_CR3
  publication-title: Circulation
  doi: 10.1161/01.CIR.102.1.42
– volume: 47
  start-page: 1757
  year: 1998
  ident: BFijo2011256_CR26
  publication-title: Diabetes
  doi: 10.2337/diabetes.47.11.1757
– volume: 79
  start-page: 790
  year: 1987
  ident: BFijo2011256_CR17
  publication-title: J Clin Invest
  doi: 10.1172/JCI112886
– volume: 179
  start-page: 269
  year: 1994
  ident: BFijo2011256_CR12
  publication-title: J Exp Med
  doi: 10.1084/jem.179.1.269
– volume: 346
  start-page: 739
  year: 2006
  ident: BFijo2011256_CR7
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2006.05.170
– volume: 55
  start-page: 216
  year: 2006
  ident: BFijo2011256_CR14
  publication-title: Diabetes
  doi: 10.2337/diabetes.55.01.06.db05-1108
– volume: 29
  start-page: 1058
  year: 2006
  ident: BFijo2011256_CR8
  publication-title: Diabetes Care
  doi: 10.2337/dc05-2068
– volume: 59
  start-page: 200
  year: 2010
  ident: BFijo2011256_CR18
  publication-title: Diabetes
  doi: 10.2337/db09-0700
– volume: 112
  start-page: 1796
  year: 2003
  ident: BFijo2011256_CR1
  publication-title: J Clin Invest
  doi: 10.1172/JCI200319246
– volume: 24
  start-page: 816
  year: 2004
  ident: BFijo2011256_CR9
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000122852.22604.78
– volume: 269
  start-page: 8477
  year: 1994
  ident: BFijo2011256_CR10
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)37218-6
– volume: 33
  start-page: 1629
  year: 2010
  ident: BFijo2011256_CR28
  publication-title: Diabetes Care
  doi: 10.2337/dc09-1392
– volume: 8
  start-page: 946
  year: 2006
  ident: BFijo2011256_CR23
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2005.10.006
– volume: 180
  start-page: 1025
  year: 1994
  ident: BFijo2011256_CR13
  publication-title: J Exp Med
  doi: 10.1084/jem.180.3.1025
– volume: 33
  start-page: 1925
  year: 2010
  ident: BFijo2011256_CR16
  publication-title: Diabetes Care
  doi: 10.2337/dc10-0340
– volume: 41
  start-page: 1241
  year: 1998
  ident: BFijo2011256_CR2
  publication-title: Diabetologia
  doi: 10.1007/s001250051058
– volume: 107
  start-page: 391
  year: 2003
  ident: BFijo2011256_CR4
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000055014.62083.05
– volume: 264
  start-page: 10867
  year: 1989
  ident: BFijo2011256_CR11
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)81700-8
– volume: 110
  start-page: 650
  year: 2011
  ident: BFijo2011256_CR25
  publication-title: J Appl Microbiol
  doi: 10.1111/j.1365-2672.2010.04922.x
– volume: 21
  start-page: 174
  year: 2006
  ident: BFijo2011256_CR6
  publication-title: Mol Cell
  doi: 10.1016/S1016-8478(23)12877-9
– volume: 98
  start-page: 3800
  year: 2001
  ident: BFijo2011256_CR24
  publication-title: Blood
  doi: 10.1182/blood.V98.13.3800
SSID ssj0005502
ssj0033214
Score 2.4833438
Snippet Objective: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the...
Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the liver. We aimed...
OBJECTIVE: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the...
International Journal of Obesity (2012) 36, 1442-1449; doi:10.1038/ijo.2011.256; published online 20 December 2011
Objective: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute-phase protein present in blood at high concentrations, known to be derived from the...
SourceID proquest
gale
pubmed
pascalfrancis
crossref
springer
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1442
SubjectTerms 631/45/287/1190
692/53
692/699/2743/393
692/699/317
Acute-Phase Proteins - metabolism
Adipose Tissue
Analysis
Animals
Binding proteins
Biological and medical sciences
Biomarkers - blood
Blood
Body Mass Index
Carrier Proteins - blood
Complications and side effects
Cross-Sectional Studies
Diabetes
Diet
Endocrinology
Enzyme-Linked Immunosorbent Assay
Epidemiology
Female
Glucagon
Glucose
Health Promotion and Disease Prevention
Humans
Immune system
Inflammation - blood
Insulin Resistance
Internal Medicine
Lipids
Male
Medical sciences
Medicine
Medicine & Public Health
Membrane Glycoproteins - blood
Metabolic Diseases
Metabolism
Mice
Nutrition research
Obesity
Obesity - blood
original-article
Peptides
Physiological aspects
Plasma
Proteins
Public Health
Risk factors
Spain
Systemic diseases
Weight control
Weight Loss
White people
Title Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance
URI https://link.springer.com/article/10.1038/ijo.2011.256
https://www.ncbi.nlm.nih.gov/pubmed/22184060
https://www.proquest.com/docview/1151342492
https://www.proquest.com/docview/1151924228
https://www.proquest.com/docview/1427004179
Volume 36
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwED7BJiEkhKD8CoxiJBhMKFoa54f7hLayaUJQTYhJfbNcx0ZBJSlN98B_z53jpKsYe6ki5Utq-c72d_H5PoA3ItE2G1sdFkrbMFHKhirjGPPkOUf2kKVz47ItptnZRfJ5ls78B7fGp1V2c6KbqIta0zfyQ2QuI55QfbuPy98hqUbR7qqX0LgNu1S6jIKvfJZvUjzSqK8lxUmRp6uKiKt-6rPgIy4Oy591W8wzJh3rK-uTn6XvLVWDPWZbqYvruOg_-6hueTp9APc9r2RHrSM8hFumGkDwqTRrts988c8Fm3a19wdw56vfVR_AYMMdEex0z5tHYCflSjtxr-oHW5RLUlP40yhN57TKwlBITesec5Ueyoq9_3J8fsBUwxT7RTk_K1ZbVre6A6E7MmMK5lPfGQb5RFzR4x7DxenJ98lZ6FUZQo1sZx0mmqfzAtc0O44tJSaakU4ynguDXZyLrIgMR0NHOhKJURaveGEii3GiRSDP-BPYqerKPANmVKIQlhfFGAOVlPwpnltj0sjEJlPjAD50tpDalywn5YyFdFvnXEi0nCTLSbRcAG979LIt1fEf3Csyq2wPmvYjXB5xZMsCKdsogHcOQWMc_08rf1QBW03VsraQe1tIHJt66_Zwy3X6dsVI_JCsCXy-8yXpJ49Gblw9gNf9bXo1JcRVpr5sMRg6x7G4AZNQVgFJzAXwtPXTTQNcaJ9FAex3jnulAdf02vObW_oC7iIybk9p7sHOenVpXiJdW8-Hbkzir5iMhrB7fDI9__YX-xw8gA
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VIgESQhBehtIuEi1FyKqz61cOCJWUKqVpxKGVejOb9S4yCnaIU6H-KX4jM-tHElF6682Kx_YoM579xjszH8Cb2Fcm7BnlplIZ15fSuDIUmPNEkUD0EAZjbastRuHgzP9yHpyvwZ-mF4bKKpuYaAN1Wij6Rr6HyKUrfJpv93H6yyXWKNpdbSg0Krc41pe_MWUrPxwdoH23OT_8fNofuDWrgKtwtZ67vhLBOMWYbHrcUGGd7io_FFGsheBRHKaeFqiop7zY19LgkUi1ZzDPMSgoQoH3vQW3fSEimtUf95dKSgKvnV0liAGomcKIKCOoq-49Ee9lP4pqeCgn3uyl9bBeFe5PZYkWMhW1xlXY9599W7scHj6EBzWOZfuV4z2CNZ13wDnI9JztsHrY6ISNmln_HbhzUu_id6CzwKoobHnWy8dg-tlMWTKx_DubZFNib7gspaK-sCzVlMLTOsvsZIksZ7vDT1_fMVkyyX5SjdGMFYYVFc-Ba1t0dMrqUns2w58JByv9BM5uxF5PYT0vcv0cmJa-RLEoTXuYGAXkv3xstA48zXUoew68b2yRqHpEOjF1TBK7VS_iBC2XkOUStJwD2630tBoN8h-5LTJrUjW2thEl2ReIzmOEiF0H3loJiin4PCXr1gjUmqZzrUhurEhiLFArpzdXXKfViyPQRHAY4_WNLyV1sCqTxavlwOv2NN2aCvByXVxUMpiqcx5fI-NTFQNR2jnwrPLThQL2U0LoObDTOO6SAlf8ay-u13QL7g5OT4bJ8Gh0_BLu4VW86hDdgPX57EK_Qqg4H2_a95PBt5sOCH8BiCZ0rA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9NADLfGkCYkhKB8BcZ2SGyAUNT0Ll99QGisVBsb0x6Y1LdwvdyhoJKUphPav8Zfh325tKsYe9tb1TipUzu-n3O2fwCv0lCZuG-Un0tl_FBK48tYYM6TJALRQxyNta22OIkPzsLPo2i0Bn_aXhgqq2xjog3UeaXoHXkXkUtPhDTfrmtcWcTpYPhh-ssnBinaaW3pNBoXOdIXvzF9q98fDtDWO5wPP33dP_Adw4CvcOWe-6ES0TjH-Gz63FCRne6pMBZJqoXgSRrngRaodKCCNNTS4CeR68BgzmNQUMQCr3sLbuNt9Yg9IRkly_KSKFjMsRLEBtROZETEEbkK_ECk3eJH1QwS5cShfWltdCvE3ams0Vqmodm4Cgf_s4drl8bhfbjnMC3ba5zwAazpsgPeoNBztsvc4NEJO2nn_ndg44vb0e9AZ4lbUdhyrtcPwewXM2WJxcrvbFJMicnhopaKesSKXFM6T2sus1MmipK9Of54-pbJmkn2k-qNZqwyrGo4D3zbrqNz5sru2Qy_Jkys9CM4uxF7PYb1sir1U2BahhLFkjzvY5IUkS_zsdE6CjTXsex78K61RabcuHRi7ZhkdttepBlaLiPLZWg5D3YW0tNmTMh_5LbJrFnT5LqILtmeQKSeIlzsefDaSlB8wd9T0rVJoNY0qWtFcnNFEuOCWjm8teI6C704gk4Eiime3_pS5gJXnS0fMw9eLg7TpakYr9TVeSODaTvn6TUyIVU0EL2dB08aP10qYF8rxIEHu63jXlLgin_t2fWabsMGhoLs-PDk6DncwZN40yy6Cevz2bl-gahxPt6yjyeDbzcdD_4Crmp5Dg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Circulating+lipopolysaccharide-binding+protein+%28LBP%29+as+a+marker+of+obesity-related+insulin+resistance&rft.jtitle=International+journal+of+obesity+%282005%29&rft.au=Moreno-Navarrete%2C+J+M&rft.au=Ortega%2C+F&rft.au=Serino%2C+M&rft.au=Luche%2C+E&rft.date=2012-11-01&rft.issn=1476-5497&rft.eissn=1476-5497&rft.volume=36&rft.issue=11&rft.spage=1442&rft_id=info:doi/10.1038%2Fijo.2011.256&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0307-0565&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0307-0565&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0307-0565&client=summon