Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins

• Published in: Thrombosis and haemostasis Vol. 99; no. 5; p. 874
• Main Authors: Mukovozov, Ilya, Sabljic, Thomas, Hortelano, Gonzalo, Ofosu, Frederick A
• Format: Journal Article
• Language: English
• Published: Germany 01.05.2008
• Subjects: Animals; Antibodies - metabolism; Antibody Formation; Chemistry, Pharmaceutical; Cloning, Molecular; Dosage Forms; Drug Administration Routes; Drug Contamination; Drug Stability; Drug Storage; Humans; Polyethylene Glycols - chemistry; Protein Processing, Post-Translational; Recombinant Fusion Proteins - administration & dosage; Recombinant Fusion Proteins - biosynthesis; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - immunology; Recombinant Fusion Proteins - therapeutic use; T-Lymphocytes - immunology

Use of recombinant human proteins has revolutionized medicine by providing over 200 highly purified hormones and proteins that effectively treat many inherited and acquired peptide hormone and protein deficiencies. With the exception of therapeutic monoclonal antibodies, these biological medicines a...