Correlation of membrane protein conformational and functional dynamics

• Published in: Nature communications Vol. 12; no. 1; p. 4363
• Main Authors: Sanganna Gari, Raghavendar Reddy, Montalvo‐Acosta, Joel José, Heath, George R., Jiang, Yining, Gao, Xiaolong, Nimigean, Crina M., Chipot, Christophe, Scheuring, Simon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.07.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 147/3; 631/1647/2204/1262; 631/57/2265; 631/57/2266; 631/57/2270/1140; 631/57/2282; 9/97; Atomic force microscopy; Biological Physics; Channel gating; Chemical Sciences; Correlation; Electrophysiology; Fluctuations; Humanities and Social Sciences; Ion channels; Ion flux; Membrane proteins; Membranes; Molecular dynamics; multidisciplinary; pH effects; Physics; Protein G; Proteins; Science; Science (multidisciplinary); Spectroscopy; Spectrum analysis; Temporal resolution

Conformational changes in ion channels lead to gating of an ion-conductive pore. Ion flux has been measured with high temporal resolution by single-channel electrophysiology for decades. However, correlation between functional and conformational dynamics remained difficult, lacking experimental tech...