Molecular basis of protein S deficiency

• Published in: Thrombosis and haemostasis Vol. 98; no. 3; p. 543
• Main Authors: García de Frutos, Pablo, Fuentes-Prior, Pablo, Hurtado, Begoña, Sala, Núria
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2007
• Subjects: Amino Acid Sequence; Blood Coagulation; Genetic Predisposition to Disease; Humans; Molecular Sequence Data; Mutation; Protein Conformation; Protein Precursors - genetics; Protein Precursors - metabolism; Protein S - genetics; Protein S - metabolism; Protein S Deficiency - blood; Protein S Deficiency - complications; Protein S Deficiency - genetics; Protein S Deficiency - metabolism; Protein Sorting Signals - genetics; Protein Structure, Tertiary - genetics; Risk Factors; Thromboembolism - blood; Thromboembolism - etiology; Thromboembolism - genetics; Thromboembolism - metabolism; Thrombosis - blood; Thrombosis - etiology; Thrombosis - genetics; Thrombosis - metabolism

Protein S deficiency (PSD) has been the most difficult to study among the classical inherited thrombophilic factors. This is in part due to the peculiar biology of protein S (PS), which has an anticoagulant role but no enzymatic activity, and because it interacts with plasma components that function...