Augmented Expression of Cyclooxygenase-2 in Human Atherosclerotic Lesions

• Published in: The American journal of pathology Vol. 155; no. 4; pp. 1281 - 1291
• Main Authors: Schönbeck, Uwe, Sukhova, Galina K., Graber, Pierre, Coulter, Stephanie, Libby, Peter
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.10.1999; ASIP; American Society for Investigative Pathology
• Subjects: Arteriosclerosis - enzymology; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blotting, Western; Cardiology. Vascular system; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Endothelium, Vascular - enzymology; Humans; Immunohistochemistry; In Situ Hybridization; Isoenzymes - biosynthesis; Isoenzymes - genetics; Macrophages - enzymology; Medical sciences; Membrane Proteins; Microcirculation - enzymology; Muscle, Smooth, Vascular - enzymology; Prostaglandin-Endoperoxide Synthases - biosynthesis; Prostaglandin-Endoperoxide Synthases - genetics; Regular; RNA, Messenger - biosynthesis; Human; Immunohistochemistry; Cell culture; Prostaglandin-endoperoxide synthase; Biochemical analysis; Enzyme; Pathogenesis; In situ; Cardiovascular disease; Inflammation; Hybridization; In vitro; Vascular disease; Pathology; Atherosclerosis; Oxidoreductases; Molecular biology

Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H 2, the precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular pathophysiology. However, knowledge of the expression of cyclooxygenases within atherosclerotic lesions is scant. This study tes...