Kank proteins: structure, functions and diseases

• Published in: Cellular and molecular life sciences : CMLS Vol. 66; no. 16; pp. 2651 - 2659
• Main Authors: Kakinuma, N, Zhu, Y, Wang, Y, Roy, B. C, Kiyama, R
• Format: Journal Article
• Language: English
• Published: Basel Basel : SP Birkhäuser Verlag Basel 01.08.2009; SP Birkhäuser Verlag Basel; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; Actin; Actins - metabolism; Adaptor Proteins, Signal Transducing; AKT protein; Alternative Splicing; Amino Acid Motifs - physiology; Ankyrin Repeat; Ankyrins; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer; Carcinoma - genetics; Carcinoma - metabolism; Carcinoma - pathology; Cell Biology; cell movement; Cloning; Cytoskeletal Proteins; Developmental disabilities; Homology; Kidney diseases; Life Sciences; Models, Biological; molecular cloning; Molecular structure; Multigene Family; Mutation; N-Terminus; neoplasm cells; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Neuromodulation; polymerization; Proteins; Renal cell carcinoma; Review; Signal Transduction; Tumor suppressor genes; Tumor Suppressor Proteins - chemistry; Tumor Suppressor Proteins - metabolism; Tumor Suppressor Proteins - physiology; Coiled-coil motif; Signal transduction; Renal cell carcinoma; Actin stress fiber; Nucleo-cytoplasmic shuttling; Ankyrin-repeat; Tumor suppressor gene

The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor...