Kank proteins: structure, functions and diseases

The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor...

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Published inCellular and molecular life sciences : CMLS Vol. 66; no. 16; pp. 2651 - 2659
Main Authors Kakinuma, N, Zhu, Y, Wang, Y, Roy, B. C, Kiyama, R
Format Journal Article
LanguageEnglish
Published Basel Basel : SP Birkhäuser Verlag Basel 01.08.2009
SP Birkhäuser Verlag Basel
Springer Nature B.V
Subjects
1-Phosphatidylinositol 3-kinase
Actin
Actins - metabolism
Adaptor Proteins, Signal Transducing
AKT protein
Alternative Splicing
Amino Acid Motifs - physiology
Ankyrin Repeat
Ankyrins
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Carcinoma - genetics
Carcinoma - metabolism
Carcinoma - pathology
Cell Biology
cell movement
Cloning
Cytoskeletal Proteins
Developmental disabilities
Homology
Kidney diseases
Life Sciences
Models, Biological
molecular cloning
Molecular structure
Multigene Family
Mutation
N-Terminus
neoplasm cells
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neuromodulation
polymerization
Proteins
Renal cell carcinoma
Review
Signal Transduction
Tumor suppressor genes
Tumor Suppressor Proteins - chemistry
Tumor Suppressor Proteins - metabolism
Tumor Suppressor Proteins - physiology
Coiled-coil motif
Signal transduction
Renal cell carcinoma
Actin stress fiber
Nucleo-cytoplasmic shuttling
Ankyrin-repeat
Tumor suppressor gene
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Abstract The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.
AbstractList The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.
The Kank family of proteins, Kank1–Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.
The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.
The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study. [PUBLICATION ABSTRACT]
Author Kakinuma, N
Kiyama, R
Roy, B. C
Wang, Y
Zhu, Y
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  fullname: Kiyama, R
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Issue 16
Keywords Coiled-coil motif
Signal transduction
Renal cell carcinoma
Actin stress fiber
Nucleo-cytoplasmic shuttling
Ankyrin-repeat
Tumor suppressor gene
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Snippet The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the...
The Kank family of proteins, Kank1–Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the...
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SubjectTerms 1-Phosphatidylinositol 3-kinase
Actin
Actins - metabolism
Adaptor Proteins, Signal Transducing
AKT protein
Alternative Splicing
Amino Acid Motifs - physiology
Ankyrin Repeat
Ankyrins
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Carcinoma - genetics
Carcinoma - metabolism
Carcinoma - pathology
Cell Biology
cell movement
Cloning
Cytoskeletal Proteins
Developmental disabilities
Homology
Kidney diseases
Life Sciences
Models, Biological
molecular cloning
Molecular structure
Multigene Family
Mutation
N-Terminus
neoplasm cells
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neuromodulation
polymerization
Proteins
Renal cell carcinoma
Review
Signal Transduction
Tumor suppressor genes
Tumor Suppressor Proteins - chemistry
Tumor Suppressor Proteins - metabolism
Tumor Suppressor Proteins - physiology
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Title Kank proteins: structure, functions and diseases
URI https://link.springer.com/article/10.1007/s00018-009-0038-y
https://www.ncbi.nlm.nih.gov/pubmed/19554261
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https://pubmed.ncbi.nlm.nih.gov/PMC11115667
Volume 66
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