Recent Progress on C-4-Modified Podophyllotoxin Analogs as Potent Antitumor Agents

• Published in: Medicinal research reviews Vol. 35; no. 1; pp. 1 - 62
• Main Authors: Liu, Ying-Qian, Tian, Jing, Qian, Keduo, Zhao, Xiao-Bo, Morris-Natschke, Susan L., Yang, Liu, Nan, Xiang, Tian, Xuan, Lee, Kuo-Hsiung
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2015; Wiley Subscription Services, Inc
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; C-4 position; Cancer; cytotoxic agents; Drug therapy; Humans; podophyllotoxin; Podophyllotoxin - analogs & derivatives; Podophyllotoxin - chemistry; Podophyllotoxin - pharmacology; reviews; Structure-Activity Relationship; podophyllotoxin; cytotoxic agents; C-4 position; reviews

Podophyllotoxin (PPT), as well as its congeners and derivatives, exhibits pronounced biological activities, especially antineoplastic effects. Its strong inhibitory effect on tumor cell growth led to the development of three of the most highly prescribed anticancer drugs in the world, etoposide, ten...