NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

• Published in: Alzheimer's & dementia Vol. 14; no. 4; pp. 535 - 562
• Main Authors: Jack, Clifford R., Bennett, David A., Blennow, Kaj, Carrillo, Maria C., Dunn, Billy, Haeberlein, Samantha Budd, Holtzman, David M., Jagust, William, Jessen, Frank, Karlawish, Jason, Liu, Enchi, Molinuevo, Jose Luis, Montine, Thomas, Phelps, Creighton, Rankin, Katherine P., Rowe, Christopher C., Scheltens, Philip, Siemers, Eric, Snyder, Heather M., Sperling, Reisa, Elliott, Cerise, Masliah, Eliezer, Ryan, Laurie, Silverberg, Nina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018
• Subjects: Alzheimer disease; Alzheimer's disease diagnosis; Alzheimer's disease imaging; Amyloid PET; autopsy; biological marker; Biomarkers Alzheimer's disease; cerebrospinal fluid; clinical research; cognition; CSF biomarkers Alzheimer's disease; diagnostic imaging; genetics; human; hypothesis; national health organization; nerve cell lesion; nerve degeneration; Neurosciences; Neurovetenskaper; nomenclature; nonhuman; personalized medicine; positron emission tomography; practice guideline; Preclinical Alzheimer's disease; priority journal; Review; staging; Tau PET; tau protein; Alzheimer's disease diagnosis; Amyloid PET; Tau PET; Preclinical Alzheimer's disease; CSF biomarkers Alzheimer's disease; Biomarkers Alzheimer's disease; Alzheimer's disease imaging

In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic recommendations for the preclinical, mild cognitive impairment, and dementia stages of Alzheimer's disease. Scientific progress in the interim led to an initiative by the National Institute on...