Droplet organelles?

• Published in: The EMBO journal Vol. 35; no. 15; pp. 1603 - 1612
• Main Authors: Courchaine, Edward M, Lu, Alice, Neugebauer, Karla M
• Format: Journal Article
• Language: English
• Published: London Blackwell Publishing Ltd 01.08.2016; Nature Publishing Group UK; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Amyotrophic lateral sclerosis; Biochemistry; Cell Physiological Phenomena; Cellular biology; Cytosol - chemistry; EMBO20; EMBO27; EMBO36; Liquid-liquid phase separation; low-complexity domain; Macromolecular Substances - metabolism; Molecular biology; Multienzyme Complexes - metabolism; nuclear bodies; Physical properties; Proteins; Review; RNP granules; Liquid‐liquid phase separation; RNP granules; nuclear bodies; low‐complexity domain

Cells contain numerous, molecularly distinct cellular compartments that are not enclosed by lipid bilayers. These compartments are implicated in a wide range of cellular activities, and they have been variously described as bodies, granules, or organelles. Recent evidence suggests that a liquid–liqu...