Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

• Published in: The EMBO journal Vol. 25; no. 9; pp. 1895 - 1905
• Main Authors: Cursi, Silvia, Rufini, Alessandra, Stagni, Venturina, Condò, Ivano, Matafora, Vittoria, Bachi, Angela, Bonifazi, Antonio Paniccià, Coppola, Luigi, Superti-Furga, Giulio, Testi, Roberto, Barilà, Daniela
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 03.05.2006; Nature Publishing Group UK; Springer Nature B.V
• Subjects: Amino Acid Sequence; Amino acids; Apoptosis; cancer; Caspase 8; Caspases - genetics; Caspases - metabolism; Colonic Neoplasms - enzymology; EMBO07; EMBO37; Enzyme Activation; ErbB Receptors - agonists; fas Receptor - pharmacology; Fas-receptor; Gene expression; Humans; Molecular Sequence Data; Mutation; Phosphates; Schizosaccharomyces - enzymology; Src non-receptor tyrosine kinase; src-Family Kinases - metabolism; Tumor Cells, Cultured; Tyrosine - metabolism; apoptosis; cancer; Fas‐receptor; Caspase‐8; Src non‐receptor tyrosine kinase

We identified Caspase‐8 as a new substrate for Src kinase. Phosphorylation occurs on Tyr380, situated in the linker region between the large and the small subunits of human Procaspase‐8, and results in downregulation of Caspase‐8 proapoptotic function. Src activation triggers Caspase‐8 phosphorylati...