Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 11; no. 34; pp. 4321 - 4333
• Main Authors: Xu, Caina, Wang, Ping, Zhang, Jingpeng, Tian, Huayu, Park, Kinam, Chen, Xuesi
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.09.2015; Wiley Subscription Services, Inc
• Subjects: Anhydrides - chemical synthesis; Anhydrides - chemistry; Animals; anticancer therapy; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; antitumor effect; Apoptosis - drug effects; Cancer; Cell Survival - drug effects; codelivery; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Doxorubicin - therapeutic use; Drug Delivery Systems; Drugs; Endocytosis - drug effects; Gene Silencing - drug effects; Hydrogen-Ion Concentration; Intracellular Space - metabolism; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Lungs; Male; Metastasis; Mice, Inbred C57BL; Nanoparticles; Nanoparticles - chemistry; Nanotechnology; Neoplasm Metastasis; Organ Size - drug effects; Particle Size; pH-sensitive; Polyethyleneimine - chemical synthesis; Polyethyleneimine - chemistry; Proto-Oncogene Proteins c-bcl-2 - metabolism; Proton Magnetic Resonance Spectroscopy; pulmonary delivery; RNA, Small Interfering - metabolism; Rodents; Static Electricity; Strategy; Tissue Distribution - drug effects; Tumors; anticancer therapy; pH-sensitive; pulmonary delivery; antitumor effect; codelivery

A pulmonary codelivery system that can simultaneously deliver doxorubicin (DOX) and Bcl2 siRNA to the lungs provides a promising local treatment strategy for lung cancers. In this study, DOX is conjugated onto polyethylenimine (PEI) by using cis‐aconitic anhydride (CA, a pH‐sensitive linker) to obta...