Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice

• Published in: EMBO molecular medicine Vol. 15; no. 3; pp. e16244 - n/a
• Main Authors: Farini, Andrea, Tripodi, Luana, Villa, Chiara, Strati, Francesco, Facoetti, Amanda, Baselli, Guido, Troisi, Jacopo, Landolfi, Annamaria, Lonati, Caterina, Molinaro, Davide, Wintzinger, Michelle, Gatti, Stefano, Cassani, Barbara, Caprioli, Flavio, Facciotti, Federica, Quattrocelli, Mattia, Torrente, Yvan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.03.2023; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: Animal models; Animals; Antibiotics; Cardiac muscle; Community structure; Digestive system; Disease; Disease Models, Animal; Duchenne muscular dystrophy; Duchenne's muscular dystrophy; Dysbacteriosis; Dysbiosis; Dystrophin; Dystrophin - genetics; EMBO12; EMBO23; EMBO25; Fibrosis; Functional foods & nutraceuticals; Gastrointestinal tract; Genotype & phenotype; Germfree; gut microbiota; Homeostasis; Immune response; Immune system; Immune System - metabolism; Immune System - pathology; immunity; Inflammation; Intestinal microflora; Intestine; Lymphocytes; Metabolic syndrome; Metabolism; Metabolites; Mice; Mice, Inbred mdx; Microbiota; Microorganisms; Motility; Muscle function; Muscle, Skeletal - metabolism; Muscular dystrophy; Muscular Dystrophy, Duchenne - genetics; Musculoskeletal system; Nitric oxide; Pathophysiology; Respiratory failure; skeletal muscle metabolism; Smooth muscle; T‐lymphocytes; T‐lymphocytes; immunity; Duchenne muscular dystrophy; gut microbiota; skeletal muscle metabolism; T-lymphocytes

Duchenne muscular dystrophy (DMD) is a progressive severe muscle‐wasting disease caused by mutations in DMD , encoding dystrophin, that leads to loss of muscle function with cardiac/respiratory failure and premature death. Since dystrophic muscles are sensed by infiltrating inflammatory cells and gu...