Relationship between Cnm-positive Streptococcus mutans and cerebral microbleeds in humans

• Published in: Oral diseases Vol. 21; no. 7; pp. 886 - 893
• Main Authors: Miyatani, F, Kuriyama, N, Watanabe, I, Nomura, R, Nakano, K, Matsui, D, Ozaki, E, Koyama, T, Nishigaki, M, Yamamoto, T, Mizuno, T, Tamura, A, Akazawa, K, Takada, A, Takeda, K, Yamada, K, Nakagawa, M, Ihara, M, Kanamura, N, Friedland, RP, Watanabe, Y
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: Adhesins, Bacterial - genetics; Aged; Brain; Carrier Proteins - genetics; Carrier State - diagnosis; Carrier State - microbiology; Cerebral Hemorrhage - diagnostic imaging; Cerebral Hemorrhage - epidemiology; Cnm-positive Streptococcus Mutans; Collagen - metabolism; collagen-binding protein; Female; Hemorrhage; Humans; intracranial hemorrhage; Magnetic Resonance Imaging; Male; microbleeds; Middle Aged; Oral Hygiene; Risk factors; Saliva - metabolism; Saliva - microbiology; Streptococcal Infections - diagnosis; Streptococcal Infections - microbiology; Streptococcus infections; Streptococcus mutans - genetics; Streptococcus mutans - metabolism; stroke; Magnetic Resonance Imaging; microbleeds; Cnm-positive Streptococcus Mutans; intracranial hemorrhage; collagen-binding protein; stroke

Objective Cerebral hemorrhage has been shown to occur in animals experimentally infected with Streptococcus mutans carrying the collagen‐binding Cnm gene. However, the relationship between cerebral microbleeds and oral hygiene, with a focus on Cnm gene‐positive S. mutans infection, remains unclear....