Lymph Node Histology and Metagenomic Sequencing in a child with Cat Scratch Disease

A 4-year-old boy presented with fever and lymphadenopathy. Despite antibiotic treatment for suspected lymphadenitis, there was minimal improvement. A lymph node biopsy revealed granulomas, raising suspicion of cat scratch disease (CSD). The boy had been scratched by a kitten a month prior. Metagenom...

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Published inQJM : An International Journal of Medicine
Main Authors Fan, Kaili, Cheng, Yiwu, Hao, Sheng
Format Journal Article
LanguageEnglish
Published England 26.09.2024
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Abstract A 4-year-old boy presented with fever and lymphadenopathy. Despite antibiotic treatment for suspected lymphadenitis, there was minimal improvement. A lymph node biopsy revealed granulomas, raising suspicion of cat scratch disease (CSD). The boy had been scratched by a kitten a month prior. Metagenomic testing of the tissue confirmed the presence of Bartonella henselae, the causative agent of CSD. It is important to incorporate molecular diagnostic tools into clinical practice for precise and timely diagnosis of infectious diseases.
AbstractList A 4-year-old boy presented with fever and lymphadenopathy. Despite antibiotic treatment for suspected lymphadenitis, there was minimal improvement. A lymph node biopsy revealed granulomas, raising suspicion of cat scratch disease (CSD). The boy had been scratched by a kitten a month prior. Metagenomic testing of the tissue confirmed the presence of Bartonella henselae, the causative agent of CSD. It is important to incorporate molecular diagnostic tools into clinical practice for precise and timely diagnosis of infectious diseases.
Author Fan, Kaili
Cheng, Yiwu
Hao, Sheng
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  organization: Department of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of medicine, Shanghai Jiao Tong University, Shanghai, China
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Cites_doi 10.1177/00099228241256169
10.1007/s15010-024-02177-1
10.3201/eid2210.160115
10.3201/eid2903.221223
10.1503/cmaj.202663
10.1111/zph.12368
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References Nelson (2024100319212302200_hcae188-B1) 2016; 22
Lin (2024100319212302200_hcae188-B2) 2024
Pizzuti (2024100319212302200_hcae188-B5) 2024; 52
Nelson (2024100319212302200_hcae188-B4) 2018; 65
Chen (2024100319212302200_hcae188-B3) 2021; 193
McCormick (2024100319212302200_hcae188-B6) 2023; 29
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Snippet A 4-year-old boy presented with fever and lymphadenopathy. Despite antibiotic treatment for suspected lymphadenitis, there was minimal improvement. A lymph...
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Title Lymph Node Histology and Metagenomic Sequencing in a child with Cat Scratch Disease
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