Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects

• Published in: Scientific reports Vol. 11; no. 1; pp. 1669 - 13
• Main Authors: Isung, Josef, Granqvist, Mathias, Trepci, Ada, Huang, Jesse, Schwieler, Lilly, Kierkegaard, Marie, Erhardt, Sophie, Jokinen, Jussi, Piehl, Fredrik
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/250/371; 692/308; 692/4017; 692/53; Adult; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Cerebrospinal fluid; Chromatography, Liquid - methods; Exercise; Exercise - physiology; Female; Humanities and Social Sciences; Humans; Immunoglobulin G; Inflammation; Inflammation - blood; Inflammation - cerebrospinal fluid; Inflammation - diagnosis; Interleukin 7; Kynurenine - metabolism; Liquid chromatography; Male; Matrix metalloproteinase; Metabolites; Metalloproteinase; Middle Aged; multidisciplinary; Neurotransmitters; Physical fitness; Plasma proteins; Proteins; Science; Science (multidisciplinary); Serine; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Vascular Endothelial Growth Factor A - cerebrospinal fluid; Young Adult

Mounting evidence shows that physical exercise modulates systemic inflammation. However, its effect on cerebrospinal fluid (CSF) immune-marker profiles in man are largely unknown. We here report a study on healthy subjects (n = 27, males = 12, mean age 28.7, range 22–52) allocated to either an acute...