Noroviruses are highly infectious but there is strong variation in host susceptibility and virus pathogenicity

• Published in: Epidemics Vol. 32; p. 100401
• Main Authors: Teunis, Peter F.M., Le Guyader, Françoise S., Liu, Pengbo, Ollivier, Joanna, Moe, Christine L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2020; Elsevier
• Subjects: Adult; Caliciviridae Infections - genetics; Caliciviridae Infections - pathology; Challenge studies; Disease Outbreaks - statistics & numerical data; Disease Susceptibility - virology; Genotype; Humans; Infectious Disease; Infectivity; Internal Medicine; Life Sciences; Multilevel dose response; Natural experiments; Norovirus; Norovirus - genetics; Norovirus - pathogenicity; Virulence; Natural experiments; Norovirus; Infectivity; Challenge studies; Multilevel dose response

•Noroviruses have been studied in human challenge experiments, to estimate infectivity.•We have shown how norovirus infectivity can also be estimated from qualifying outbreaks.•This study combines challenge studies and natural experiments to quantify infectivity.•Secretor negatives are clearly prote...