Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS–EEG

• Published in: NeuroImage (Orlando, Fla.) Vol. 103; pp. 152 - 162
• Main Authors: Premoli, Isabella, Rivolta, Davide, Espenhahn, Svenja, Castellanos, Nazareth, Belardinelli, Paolo, Ziemann, Ulf, Müller-Dahlhaus, Florian
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.12.2014; Elsevier; Elsevier Limited
• Subjects: Adult; Baclofen; Biological and medical sciences; Brain; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Cortex (motor); Cross-Over Studies; Diazepam; Double-Blind Method; Drug dosages; EEG; Electroencephalography; Electromyography; Epilepsy; Event-related potentials; Evoked Potentials, Motor - physiology; Excitability; Experiments; Fundamental and applied biological sciences. Psychology; GABA-A Receptor Agonists - pharmacology; GABA-A Receptor Antagonists - pharmacology; Humans; Magnetic fields; Male; Mental disorders; Neural Inhibition - physiology; Neurotransmission; Physiology; Receptors, GABA-A - metabolism; Receptors, GABA-B - metabolism; Schizophrenia; Signal Processing, Computer-Assisted; Studies; Synaptic Transmission - drug effects; Synaptic Transmission - physiology; Transcranial Magnetic Stimulation; Vertebrates: nervous system and sense organs; Young Adult; γ-Aminobutyric acid A receptors; γ-Aminobutyric acid B receptors; United Kingdom > UK; Characterization; Human; Electrophysiology; Electroencephalography; Gabaergic receptor B; Neurotransmission

GABAB-receptor (GABABR) mediated inhibition is important in regulating neuronal excitability. The paired-pulse transcranial magnetic stimulation (TMS) protocol of long-interval intracortical inhibition (LICI) likely reflects this GABABergic inhibition. However, this view is based on indirect evidenc...